ChemicalBook > CAS DataBase List > antibiotic 1233A

antibiotic 1233A

Product Name
antibiotic 1233A
CAS No.
29066-42-0
Chemical Name
antibiotic 1233A
Synonyms
699;F-244;1233A;L-659699;Hymeglusin;Antibiotic F-244;antibiotic 1233A;(R,R)-HyMeglusin;(R,R)-Hymeglusin, antibiotic agent;(2E,4E,7R)-11-[(2R,3R)-3-Hydroxymethyl-4-oxooxetan-2-yl]-3,5,7-trimethyl-2,4-undecadienoic acid
CBNumber
CB41355000
Molecular Formula
C18H28O5
Formula Weight
324.41
MOL File
29066-42-0.mol
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antibiotic 1233A Property

Boiling point:
516.6±15.0 °C(Predicted)
Density 
1.101±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
powder
pka
4.98±0.33(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Safety

WGK Germany 
3
RTECS 
YQ1170000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0301
Product name
Hymeglusin
Purity
≥98% (HPLC)
Packaging
1mg
Price
$368.6
Updated
2025/07/31
Cayman Chemical
Product number
11899
Product name
Hymeglusin
Purity
≥95%
Packaging
500μg
Price
$124
Updated
2024/03/01
Cayman Chemical
Product number
11899
Product name
Hymeglusin
Purity
≥95%
Packaging
1mg
Price
$211
Updated
2024/03/01
Cayman Chemical
Product number
11899
Product name
Hymeglusin
Purity
≥95%
Packaging
2.5mg
Price
$496
Updated
2024/03/01
Usbiological
Product number
452114
Product name
Hymeglusin
Packaging
1mg
Price
$496
Updated
2021/12/16
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antibiotic 1233A Chemical Properties,Usage,Production

Description

Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg).1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4

Uses

Hymeglusin is an irreversible HMG-CoA synthase inhibitor.

Definition

ChEBI: Hymeglusin is a long-chain fatty acid.

in vivo

At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %[2].

storage

+4°C

References

[1] M D GREENSPAN. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 21: 7488-7492. DOI:10.1073/pnas.84.21.7488
[2] HIROSHI TOMODA. Binding site for fungal β-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2004, 1636 1: Pages 22-28. DOI:10.1016/j.bbalip.2003.11.005
[3] D. ANDREW SKAFF. Biochemical and Structural Basis for Inhibition of Enterococcus faecalis Hydroxymethylglutaryl-CoA Synthase, mvaS, by Hymeglusin[J]. Biochemistry Biochemistry, 2012, 51 23: 4713-4722. DOI:10.1021/bi300037k
[4] CHRISTOPHER ROTHWELL . Cholesterol biosynthesis modulation regulates dengue viral replication[J]. Virology, 2009, 389 1: Pages 8-19. DOI:10.1016/j.virol.2009.03.025

antibiotic 1233A Preparation Products And Raw materials

Raw materials

Preparation Products

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antibiotic 1233A Suppliers

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29066-42-0, antibiotic 1233ARelated Search:

Simvastatin Zafirlukast Prostaglandin E2 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID

  • 1233A
  • Antibiotic F-244
  • F-244
  • L-659699
  • (R,R)-HyMeglusin
  • (2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid
  • Hymeglusin
  • (2E, 4E, 7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid
  • antibiotic 1233A
  • (2E,4E,7R)-11-[(2R,3R)-3-Hydroxymethyl-4-oxooxetan-2-yl]-3,5,7-trimethyl-2,4-undecadienoic acid
  • 2,4-Undecadienoic acid, 11-[(2R,3R)-3-(hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-, (2E,4E,7R)-
  • 699
  • (R,R)-Hymeglusin, antibiotic agent
  • 29066-42-0