benastatin B

Product Name: benastatin B
CAS No.: 138968-86-2
Chemical Name: benastatin B
Synonyms: benastatin B;Benzo[a]naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-13,13-dimethyl-8-oxo-3-pentyl-
CBNumber: CB41356395
Molecular Formula: C30H30O7
Formula Weight: 502.55
MOL File: 138968-86-2.mol

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benastatin B Property

Boiling point:: 759.3±60.0 °C(Predicted)
Density: 1.372±0.06 g/cm3(Predicted)
storage temp.: -20°C
pka: 2.99±0.40(Predicted)
form: A powder

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Hazard and Precautionary Statements (GHS)

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benastatin B Chemical Properties,Usage,Production

Uses

Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC50 of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC50 of 79 μg/mL[1][2].

References

[1] Aoyama T, et al., Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B. J Antibiot (Tokyo). 1992 Sep;45(9):1391-6. DOI:10.7164/antibiotics.45.1391
[2] Tsakem B, et al., Structures, biosynthesis and biological activities of benastatins, anthrabenzoxocinones and fredericamycins. Bioorg Chem. 2024 Sep;150:107572. DOI:10.1016/j.bioorg.2024.107572

benastatin B Preparation Products And Raw materials

Raw materials

Preparation Products

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benastatin B Suppliers

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ChemeGen

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138968-86-2, benastatin BRelated Search:

4-Methylsalicylic acid emodin anthrone 4-(3-METHYLPHENYL)BENZALDEHYDE 3,3',4,4'-TETRAMETHYLBIPHENYL 10,10-Dimethylanthrone 4-PHENYL ETHYL BENZOIC ACID 3-ISOPROPYLBIPHENYL 2,2',5,5'-TETRAMETHYLBIPHENYL 4-Benzoylbiphenyl 3-PHENYLSALICYLIC ACID 4-(4-N-BUTYLPHENYL)BENZALDEHYDE 2'-METHYLBIPHENYL-3-CARBOXYLIC ACID 3',4'-DIMETHYL-BIPHENYL-3-CARBALDEHYDE benastatin B 4'-ETHYLBIPHENYL-4-CARBOXALDEHYDE (4'-METHYLBIPHENYL-3-YL)-METHANOL 4'-FORMYL-BIPHENYL-3-CARBOXYLIC ACID 1,2-BIS(3,4-DIMETHYLPHENYL)ETHANE

benastatin B

Benzo[a]naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-13,13-dimethyl-8-oxo-3-pentyl-

138968-86-2