ASOXIME CHLORIDE

Product Name: ASOXIME CHLORIDE
CAS No.: 34433-31-3
Chemical Name: ASOXIME CHLORIDE
Synonyms: hi6;hj6;hi-6;Transant;wr249655;Ccris 7699;HI 6 Chloride;hi-6dichloride;ASOXIME CHLORIDE;Asoxime dichloride
CBNumber: CB4137803
Molecular Formula: C14H16Cl2N4O3
Formula Weight: 359.21
MOL File: 34433-31-3.mol

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ASOXIME CHLORIDE Property

Melting point:: 145-147°C
storage temp.: -20°C
solubility: H2O: soluble15mg/mL (clear solution)
form: powder
color: white to beige
Water Solubility: H2O: 15mg/mL (clear solution)
Stability:: 1-10% Aqueous solution

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0224
Product name: HI-6
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $122
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0224
Product name: HI-6
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $491
Updated: 2024/03/01

Cayman Chemical

Product number: 18607
Product name: Asoxime (chloride)
Purity: ≥95%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18607
Product name: Asoxime (chloride)
Purity: ≥95%
Packaging: 10mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 18607
Product name: Asoxime (chloride)
Purity: ≥95%
Packaging: 25mg
Price: $216
Updated: 2024/03/01

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ASOXIME CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Cholinesterase reactivator. A potential antidote for organophosphate poisoning

General Description

HI-6 functions as an antidote for treating intoxication caused by nerve agents. It acts as a potent drug in radiation protection and suppresses oxidative stress. HI-6 prevents the toxicity of the antineoplastic drug irinotecan.

Biological Activity

asoxime, also known as hi-6, is an asymmetric bis-pyridinium aldoxime and reactivates ache via nucleophilic attack of oximate anions on organophosphate-ache conjugates.ache, one of the primary targets of organophosphates, is inactivated by organophosphates via reacting covalently with the active center serine, which blocks the hydrolyzation of acetylcholine at peripheral and central synapses. additionally, the accumulation of acetylcholine leads to an over-stimulation of cholinergic receptors, which disrupts a variety of biological functions.

Biochem/physiol Actions

HI-6 is an efficient oxime cholinesterase reactivator that is used as an antidote for organophosphates (Ops) exposure.

in vitro

hi-6 showed a bacteriostatic effect on francisella tularensis (f. tularensis) and inhibited the growth of f. tularensis when treated with 100 mm hi-6 [1].

in vivo

female balb/c mice, infected by f. tularensis, were administrated subcutaneously with 100 μl hi-6 for ten days. the lower dose of hi-6 yielded in different symptoms and mortality. compared to mice injected only with tularemia, groups of mice exposed to the lower dose of hi-6 showed a decline in mortality, which can be explained via higher efficacy of bacteriostatic effect while the toxic effect was decreased [1]. female wistar rats were treated intramuscularly with hi-6 at a dose of 15.6 or 156 mg/kg for one day. the level of thiobarbituric acid reactive substances was increased, which was triggered by hi-62 [2].

IC 50

8.9 μm: blocks ache in human; 126 μm: inhibits acetylcholinesterase (ache) in bovine; 160 μm: blocks muscarinic acetylcholine receptor m1, m2, m3 and m4 in mouse.

References

[1]. pohanka, m., pavli, o., pikula, j., treml, f., & kuca, k. modulation of tularemia disease progress by the bisquaternary pyridinium oxime hi-6. acta veterinaria brno. 2010; 79(3): 443-448.
[2]. pohanka, m., sobotka, j., svobodova, h., & stetina, r. sulfur mustard induced oxidative stress and its alteration using asoxime (hi-6). interdisciplinary toxicology. 2013; 6(4).

ASOXIME CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ASOXIME CHLORIDE Suppliers

Canada 1 China 26 Germany 1 India 1 South Korea 1 United Kingdom 3 United States 10 USA 1 Global 44

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34433-31-3, ASOXIME CHLORIDERelated Search:

Angeli’s Salt Pralidoxime Chloride 1-(((4-(Aminocarbonyl)pyridinio)methoxy)methyl)pyridinium dichloride ASOXIME CHLORIDE Asoxime-d4 Chloride

HI 6 Chloride

1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride

4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride

Transant

(((4-(iminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)pyridi

4’-carbamoyl-2-formyl-1,1’-(oxydimethylene)di-pyridinium-dichloride-2-oxime

hi6

hi-6

hi-6dichloride

(((4-(Iminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)pyridinium dichloride

1-(2-Hydroxyiminomethyl-1-pyridino)-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate

Ccris 7699

hj6

pyridinium,1-(((4-(aminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)

pyridinium,4’-carbamoyl-2-formyl-1,1’-(oxydimethylene)di-,dichloride,2-oxi

pyridinium,4’-carbamoyl-2-formyl-1,1’-(oxydimethylene)di-,dichloride,2-oxime

wr249655

1[[[4-(AMINOCARBONYL)PYRIDINIO]METHOXY]METHYL]-2-[(HYDROXYIMINO)METHYL]PYRIDINIUM DICHLORIDE

ASOXIME CHLORIDE

1-(4-Carbamoylpyridiniomethoxymethyl)-2-(hydroxyiminomethyl)pyridinium·2chloride

1-[(4-Carbamoylpyridinium-1-yl)methoxymethyl]-2-(hydroxyiminomethyl)pyridinium·2chloride

Asoxime dichloride

34433-31-3

C14H16N4O32Cl

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