dehydrocurdione

Product Name: dehydrocurdione
CAS No.: 38230-32-9
Chemical Name: dehydrocurdione
Synonyms: dehydrocurdione;6,10-Dimethyl-3-isopropylidene-6-cyclodecene-1,4-dione;(6Z,10S)-3-Isopropylidene-6,10-dimethyl-6-cyclodecene-1,4-dione;6-Cyclodecene-1,4-dione, 6,10-dimethyl-3-(1-methylethylidene)-, (6E,10S)-
CBNumber: CB41390108
Molecular Formula: C15H22O2
Formula Weight: 234.33
MOL File: 38230-32-9.mol

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dehydrocurdione Property

LogP: 2.433 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PXT0001931
Product name: DEHYDROCURDIONE
Purity: 95.00%
Packaging: 5MG
Price: $499.61
Updated: 2021/12/16

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dehydrocurdione Chemical Properties,Usage,Production

Uses

Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].

in vivo

Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis^[2].
Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema^[2].

Animal Model:	Wistar rats^[2]
Dosage:	120 mg/kg
Administration:	P.o ; daily for 12 days
Result:	Significantly reduces chronic adjuvant arthritis.

References

[1] Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897. DOI:10.1002/ptr.6028
[2] Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481. DOI:10.1007/s000110050361

dehydrocurdione Preparation Products And Raw materials

Raw materials

Preparation Products

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dehydrocurdione Suppliers

China 22 United States 1 USA 1 Global 24

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38230-32-9, dehydrocurdioneRelated Search:

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dehydrocurdione

6,10-Dimethyl-3-isopropylidene-6-cyclodecene-1,4-dione

6-Cyclodecene-1,4-dione, 6,10-dimethyl-3-(1-methylethylidene)-, (6E,10S)-

(6Z,10S)-3-Isopropylidene-6,10-dimethyl-6-cyclodecene-1,4-dione

38230-32-9