chrysosplenetin B
Occurance- Product Name
- chrysosplenetin B
- CAS No.
- 603-56-5
- Chemical Name
- chrysosplenetin B
- Synonyms
- EMD-20940;chrysoplenetin;chrgsosplenetin B;chrysosplenetin B;Chrysosplenetin, 10 mM in DMSO;3,6,7,3'-Tetramethylquercetagetin;5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxychromen-4-one;5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-one;4H-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-;5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
- CBNumber
- CB41396579
- Molecular Formula
- C19H18O8
- Formula Weight
- 374.34
- MOL File
- 603-56-5.mol
chrysosplenetin B Property
- Melting point:
- 203-205 °C
- Boiling point:
- 615.8±55.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble; Methanol: soluble
- form
- A crystalline solid
- pka
- 6.13±0.40(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C19H18O8/c1-23-11-7-9(5-6-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
- InChIKey
- NBVTYGIYKCPHQN-UHFFFAOYSA-N
- SMILES
- O=C1C(=C(C2C=CC(=C(C=2)OC)O)OC2=CC(=C(C(=C21)O)OC)OC)OC
- LogP
- 3.037 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C3874
- Product name
- Chrysosptertin B
- Packaging
- 25MG
- Price
- $432
- Updated
- 2025/07/31
- Product number
- PXT0002313
- Product name
- CHRYSOSPLENETIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.5
- Updated
- 2021/12/16
- Product number
- CS-0016903
- Product name
- Chrysosplenetin
- Purity
- 99.52%
- Packaging
- 10mg
- Price
- $504
- Updated
- 2021/12/16
- Product number
- CS-0016903
- Product name
- Chrysosplenetin
- Purity
- 99.52%
- Packaging
- 20mg
- Price
- $857
- Updated
- 2021/12/16
- Product number
- CS-0016903
- Product name
- Chrysosplenetin
- Purity
- 99.52%
- Packaging
- 5mg
- Price
- $297
- Updated
- 2021/12/16
chrysosplenetin B Chemical Properties,Usage,Production
Occurance
Chrysosplenetin B is a tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin. It has a role as an antiviral agent and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It derives from a quercetagetin.
Chrysosplenetin B is an O-methylated flavonol. It can be found in the root of Berneuxia thibetica and in Chamomilla recutita.
Chemical Properties
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Laggera pterodonta.
Uses
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
Definition
ChEBI: A tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin.
IC 50
CYP3A
References
[1] Ma L, et al. Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine. Pharm Biol. 2017 Dec;55(1):374-380. DOI:10.1080/13880209.2016.1241810
chrysosplenetin B Preparation Products And Raw materials
Raw materials
Preparation Products
chrysosplenetin B Suppliers
- Tel
- 0572-8889530 18167260939
- zsubio@163.com
- Country
- China
- ProdList
- 392
- Advantage
- 58
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- +86-028-82633397 18982077548
- Fax
- +86-28-82633165
- cwb1@biopurify.cn
- Country
- China
- ProdList
- 2376
- Advantage
- 60
- Tel
- 021-38218169 13341702378
- Fax
- QQ：190129269
- winherb@126.com
- Country
- China
- ProdList
- 1245
- Advantage
- 58
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3988
- Advantage
- 66
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 702-983-3769
- Fax
- 702-983-3769
- sales@albtechnology.com
- Country
- United States
- ProdList
- 2993
- Advantage
- 55
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 6905
- Advantage
- 55
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8447
- Advantage
- 60
View Lastest Price from chrysosplenetin B manufacturers
- Product
- Chrysosplenetin 603-56-5
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2025-08-14
- Product
- Chrysosplenetin B 603-56-5
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥90%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-08
- Product
- chrysosplenetin 603-56-5
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09