sepimostate mesilate

Product Name: sepimostate mesilate
CAS No.: 103926-82-5
Chemical Name: sepimostate mesilate
Synonyms: FUT-187;Sepimostat Mesylate;Sepinostat mesilate;sepimostate mesilate;Sepimostat (dimethanesulfonate );6-Carbamimidoylnaphthalen-2-yl 4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzoate dimethanesulfonate
CBNumber: CB41400751
Molecular Formula: C21H19N5O2.2CH4O3S
Formula Weight: 565.625
MOL File: 103926-82-5.mol

More

Less

sepimostate mesilate Property

Melting point:: 248-250°
storage temp.: Store at -20°C

More

Less

Safety

Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 39.4, 41.4, 21.8, 15.8 i.v.; 6284, 5492, 6799, 3343 s.c.; 4395, 3626, 4653, 3761 orally (Terazawa)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0127913
Product name: Sepimostat(dimethanesulfonate)
Packaging: 25mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0127913
Product name: Sepimostat(dimethanesulfonate)
Packaging: 50mg
Price: $1550
Updated: 2021/12/16

Ambeed

Product number: A1448620
Product name: 6-Carbamimidoylnaphthalen-2-yl4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzoatedimethanesulfonate
Purity: 98%
Packaging: 50mg
Price: $1500
Updated: 2021/12/16

More

Less

sepimostate mesilate Chemical Properties,Usage,Production

Uses

Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7μM[1].

in vivo

Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect^[1].

Animal Model:	Male Sprague Dawley rats weighing 150-300g^[1].
Dosage:	Intravitreal injection.
Administration:	1 to 100 nmol/eye.
Result:	Exhibited neuroprotective effects significantly.

References

[1] Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409. DOI:10.1038/s41598-019-56905-x

sepimostate mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

sepimostate mesilate Suppliers

China 11 South Korea 1 United States 3 Global 15

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9663
Advantage: 55

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Aikon International Limited

Tel: 17714375163
Email: hywu@aikonchem.com
Country: China
ProdList: 10656
Advantage: 58

Hunan Hui Bai Yi New Materials Co., Ltd

Tel: 0745-2866551 19976851779
Email: 3643281807@qq.com
Country: China
ProdList: 7302
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 17391631969
Email: 1023@dideu.com
Country: China
ProdList: 9279
Advantage: 58

103926-82-5, sepimostate mesilateRelated Search:

sepimostate mesilate

FUT-187

Sepinostat mesilate

Sepimostat Mesylate

Sepimostat (dimethanesulfonate )

6-Carbamimidoylnaphthalen-2-yl 4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzoate dimethanesulfonate

103926-82-5