1-(ETHOXYCARBONYLMETHYL)PIPERAZINE

Product Name: 1-(ETHOXYCARBONYLMETHYL)PIPERAZINE
CAS No.: 40004-08-8
Chemical Name: 1-(ETHOXYCARBONYLMETHYL)PIPERAZINE
Synonyms: AKOS BC-0535;AKOS BBS-00006885;ETHYL PIPERAZINOACETATE;ETHYL 1-PIPERAZINEACETATE;Ethyl 2-Piperazinoacetate;ethyl piperazine-1-acetate;Ethyl 1-Piperazinylacetate;ETHYL PIPERAZIN-1-YLACETATE;ethyl (1-piperazino)acetate;Ethyl 1-piperazineacetate-96%
CBNumber: CB4140276
Molecular Formula: C8H16N2O2
Formula Weight: 172.22
MOL File: 40004-08-8.mol

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1-(ETHOXYCARBONYLMETHYL)PIPERAZINE Property

Boiling point:: 127°C 13mm
Density: 1.048 g/mL at 20 °C (lit.)
refractive index: n20/D 1.472
Flash point:: 127°C/13mm
storage temp.: -20°C
solubility: Chloroform, Methanol
form: Oil
pka: 8.96±0.10(Predicted)
color: Clear
Water Solubility: Soluble in water, chloroform, and methanol.
Sensitive: Air Sensitive
BRN: 743260
Major Application: peptide synthesis
InChI: 1S/C8H16N2O2/c1-2-12-8(11)7-10-5-3-9-4-6-10/h9H,2-7H2,1H3
InChIKey: MTFCXMJOGMHYAE-UHFFFAOYSA-N
SMILES: CCOC(=O)CN1CCNCC1
CAS DataBase Reference: 40004-08-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
HS Code: 2933599590
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 61897
Product name: Ethyl piperazinoacetate
Purity: ≥95.0% (GC)
Packaging: 5G
Price: $130
Updated: 2025/07/31

Sigma-Aldrich

Product number: 61897
Product name: Ethyl piperazinoacetate
Purity: ≥95.0% (GC)
Packaging: 25g
Price: $424
Updated: 2023/06/20

TRC

Product number: E891400
Product name: N-(Ethoxycarbonylmethyl)piperazine
Packaging: 1g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR4184
Product name: Ethyl(piperazin-1-yl)acetate
Packaging: 1g
Price: $15
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-W9
Product name: Ethyl (piperazin-1-yl)acetate
Packaging: 1g
Price: $16
Updated: 2021/12/16

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1-(ETHOXYCARBONYLMETHYL)PIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

1-(ETHOXYCARBONYLMETHYL)PIPERAZINE is Clear Thick Oil

Uses

N-(Ethoxycarbonylmethyl)piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents.

Uses

1-(ETHOXYCARBONYLMETHYL)PIPERAZINE is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selecti ve inducers of apoptosis and activators of procaspases for use as anticancer agents.

Definition

ChEBI: Ethyl piperazinoacetate is an alpha-amino acid ester.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Step A: tert-butyl 4-ethoxycarbonylmethyl-piperazine-1-carboxylate

Tert-butyl piperazine-1-carboxylate (2.62 g, 14 mmol), cesium carbonate (5 g, 15 mmol) and bromoacetic acid ethyl ester (1.56 ml, 14 mmol) were stirred at room temperature for 1 hour. The mixture was dissolved in water (200 ml) and ethyl ether (2 x 100 ml) was partitioned between them. The combined organic phases were dried over magnesium sulfate and concentrated to give yellow oil, which was crystallized to give tert-butyl 4-ethoxycarbonylmethyl-piperazine-1-carboxylate (2.6 g) in the form of a pale yellow solid.

1H N.M.R (CDCl3) ?? = 1.24 (3H, t, J = 7.1 Hz), 1.43 (9H, s), 2.49 (4H, t, J = 5 Hz), 3.20 (2H, s), 3.44 (4H, t, J = 4.8 Hz), 4.16 (2H, q, J = 7.1 Hz).

Step B: 1-(Ethoxycarbonylmethyl)piperazine

A solution of tert-butyl 4-ethoxycarbonylmethyl-piperazine-1-carboxylate in 90% trifluoroacetic acid (5 ml) was stirred for 3 hours. The mixture was alkalized with saturated sodium bicarbonate solution and concentrated. The residue was ground with ethyl acetate (30 ml) and filtered. The filtrate was concentrated to give 1-(ethoxycarbonylmethyl)piperazine in the form of a yellow oil (about 1.5 g).

1-(ETHOXYCARBONYLMETHYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(ETHOXYCARBONYLMETHYL)PIPERAZINE Suppliers

Canada 1 China 84 Europe 2 Germany 4 India 8 Switzerland 1 The Netherlands 1 Ukraine 3 United Kingdom 8 United States 19 Global 131

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View Lastest Price from 1-(ETHOXYCARBONYLMETHYL)PIPERAZINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: ETHYL 1-PIPERAZINEACETATE 40004-08-8
Price: US $1.00-1.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2024-08-16

40004-08-8, 1-(ETHOXYCARBONYLMETHYL)PIPERAZINERelated Search:

3-ETHOXYCARBONYLMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-ETHOXYCARBONYLMETHYL PIPERAZINE PIPERAZIN-1-YL-ACETIC ACID ETHYL ESTER 2HCL H2O BUTTPARK 19\07-50 1-BENZYL-4-(ETHOXYCARBONYLMETHYL)PIPERAZINE RARECHEM AH CK 0173 ethyl 2-(4-methylpiperazin-1-yl)acetate 2-(4-BENZYL-PIPERAZIN-1-YL)-2-OXO-ACETIC ACID ETHYL ESTER ethyl 2-(4-phenylpiperazin-1-yl)acetate cinepazet ETHYL 2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)ACETATE 2(3H)-Furanone, dihydro-5-(4-chlorophenyl)-3-(4-(3-chlorophenyl)-1-pip erazinyl)-, monohydrochloride 1-(ETHOXYCARBONYLMETHYL)PIPERAZINE 4-((4-Methyl-1-piperazinyl)acetoxymethyl)-2'-chlorobiphenyl dihydrogen maleate ETHYL 2-[4-[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINO]PROPANOATE

AKOS BC-0535

AKOS BBS-00006885

1-(ETHOXYCARBONYLMETHYL)PIPERAZINE

2-(PIPERAZIN-1-YL)-ACETIC ACID ETHYL ESTER

ETHYL 2-(PIPERAZIN-1-YL)ACETATE

ETHYL PIPERAZIN-1-YLACETATE

ETHYL PIPERAZINOACETATE

ETHYL 1-PIPERAZINEACETATE

N-(CARBOETHOXYMETHYL)-PIPERAZINE

N-(Carboethoxymethyl)piperazine~Ethyl (1-piperazino)acetate~(1-Piperazino)acetic acid ethyl ester

ethyl piperazine-1-acetate

2-(PIPERAZIN-1-YL)-ACETIC ACID ETHYL ESTER >97%

1-(Ethoxycarbonylmethyl)piperazine, N-(Carboethoxymethyl)-piperazine, Ethyl 1-piperazineacetate

1-Piperazineacetic acid ethyl ester

4-(CarboethoxyMethyl)piperazine

Ethyl 1-Piperazinylacetate

Ethyl 2-Piperazinoacetate

ethyl (1-piperazino)acetate

1-Piperazineaceticacid,ethylester(7CI,9CI)

N-(EthoxycarbonylMethyl)piperazine

Piperazin-1-ylacetic Acid Ethyl Ester

Ethyl piperazinoacetate >=95.0% (GC)

2-(1-piperazinyl)acetic acid ethyl ester

ethyl 2-piperazin-1-ylethanoate

Ethyl 1-piperazineacetate-96%

2-(Piperazin-1-yl)-acetic acid ethyl

40004-08-8

Peptide Synthesis

Others

Specialty Synthesis

Unnatural Amino Acid Derivatives

PIPERIDINE

1