7-HYDROXYBENZO(A)PYRENE Property

Melting point:

218.5°C

Boiling point:

371.47°C (rough estimate)

Density 

1.0921 (rough estimate)

refractive index 

1.6220 (estimate)

storage temp. 

Refrigerator

solubility 

Dichlorormethane (Slightly), DMSO (Slightly)

form 

Solid

pka

9.40±0.30(Predicted)

color 

Yellow plates from C6H6/pet ether

Safety

Toxicity

mmo-sat 16 mg/plate MUREAV 36,379,76

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

7-HYDROXYBENZO(A)PYRENE Chemical Properties,Usage,Production

Uses

7-Hydroxybenzo[a]pyrene is a metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer.

Definition

ChEBI: 7-Hydroxybenzo[a]pyrene is an ortho- and peri-fused polycyclic arene.

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 4157, 1981 DOI: 10.1021/jo00334a010

Safety Profile

Questionable carcinogen withexperimental tumorigenic and neoplastigenic data by skincontact. Human mutation data reported. When heated todecomposition it emits acrid smoke and fumes.