1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol
- Product Name
- 1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol
- CAS No.
- 144261-13-2
- Chemical Name
- 1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol
- Synonyms
- 3,5-(Trans-4-propylcyclohexyl)difluorobenzene;1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol;1,3-DIFLUORO-5-(TRANS-4-PROPYLCYCLOHEXYL)-BENZOL;1,3-difluoro-5-(trans-4-propylcyclohexyl)benzene;Benzene, 1,3-difluoro-5-(trans-4-propylcyclohexyl)-
- CBNumber
- CB41448335
- Molecular Formula
- C15H20F2
- Formula Weight
- 238.32
- MOL File
- 144261-13-2.mol
1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol Property
- Boiling point:
- 279.1±33.0 °C(Predicted)
- Density
- 1.022±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- InChI
- InChI=1S/C15H20F2/c1-2-3-11-4-6-12(7-5-11)13-8-14(16)10-15(17)9-13/h8-12H,2-7H2,1H3/t11-,12-
- InChIKey
- GHOUEKQRKXYGHJ-HAQNSBGRSA-N
- SMILES
- C1(F)=CC([C@@H]2CC[C@@H](CCC)CC2)=CC(F)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2481AQ
- Product name
- 1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol
- Packaging
- 25g
- Price
- $374
- Updated
- 2021/12/16
- Product number
- CM249449
- Product name
- 1,3-Difluoro-5-(trans-4-propylcyclohexyl)benzene
- Purity
- 95+%
- Packaging
- 100g
- Price
- $505
- Updated
- 2021/12/16
- Product number
- 144261132
- Product name
- 1,3-Difluoro-5-(trans-4-propylcyclohexyl)benzene
- Packaging
- 100g
- Price
- $556.2
- Updated
- 2021/12/16
- Product number
- A113781
- Product name
- 1,3-Difluoro-5-(trans-4-propylcyclohexyl)benzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $6
- Updated
- 2021/12/16
- Product number
- AS025844
- Product name
- 1,3-Difluoro-5-(trans-4-propylcyclohexyl)benzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $6
- Updated
- 2021/12/16
1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Synthesis
148150-92-9
144261-13-2
Under nitrogen protection, 132 g of crude 1-(1-hydroxy-4-propylcyclohexyl)-3,5-difluorobenzene was dissolved with 2.99 g of p-toluenesulfonic acid monohydrate in 250 mL of toluene. The reaction mixture was heated and refluxed and stirred for 2 hours while the water generated was removed via a water separator. Upon completion of the reaction, the solution was cooled to room temperature and the organic layer was washed with saturated aqueous sodium bicarbonate and saturated saline in turn. The organic layer was dried over anhydrous sodium sulfate and the solvent was removed by distillation under reduced pressure. The residue was completely dissolved in 280 mL of ethyl acetate, and 7.1 g of 5% palladium/carbon catalyst was added, and the reaction was stirred under hydrogen atmosphere (5 MPa pressure) for 6 hours. At the end of the reaction, the palladium catalyst was removed by filtration and the filtrate was distilled under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography. The purified product was dissolved with 3.39 g of potassium tert-butoxide in 350 mL of DMF and the reaction was stirred at room temperature for 4 hours. After the reaction was completed, water and hexane were added for liquid-liquid separation. The aqueous layer was extracted with hexane, the organic layer and hexane extract were combined and washed with saturated saline. The organic layer was dried over anhydrous sodium sulfate and then distilled under reduced pressure to remove the solvent and further distilled at 206 Pa pressure (boiling point 110 °C to 112 °C) to give 58.05 g of 1-(trans-4-propylcyclohexyl)-3,5-difluorobenzene.
References
[1] Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2001, vol. 364, p. 899 - 910
[2] Patent: US2014/275577, 2014, A1. Location in patent: Paragraph 0104; 0106
[3] Patent: JP6085912, 2017, B2. Location in patent: Paragraph 0063; 0064; 0066
1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol manufacturers
- Product
- 1,3-Difluor-5-(trans-4-propylcyclohexyl)-benzol 144261-13-2
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2025-06-13