Adaphostin

Product Name: Adaphostin
CAS No.: 241127-58-2
Chemical Name: Adaphostin
Synonyms: Adaphostin;1-Adamantyl 4-((2;5-Dihydroxybenzyl)Amino)Benzoate;1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate;Adamantan-1-yl 4-((2,5-dihydroxybenzyl)amino)benzoate;1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate;4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester;Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
CBNumber: CB41456086
Molecular Formula: C24H27NO4
Formula Weight: 393.48
MOL File: 241127-58-2.mol

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Adaphostin Property

storage temp.: Desiccate at +4°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1110
Product name: Adaphostin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $76.57
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1110
Product name: Adaphostin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $317
Updated: 2022/05/15

TRC

Product number: A225020
Product name: Adaphostin
Packaging: 250mg
Price: $1320
Updated: 2021/12/16

Usbiological

Product number: 254543
Product name: Adaphostin
Packaging: 10mg
Price: $403
Updated: 2021/12/16

Usbiological

Product number: 001651
Product name: Adaphostin
Packaging: 25mg
Price: $460
Updated: 2021/12/16

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Adaphostin Chemical Properties,Usage,Production

Uses

Novel antitumor agent that induces apoptosis in tumor cells through inhibition of the tyrosine kinase BCR/ABL.

Biological Functions

Adaphostin is a p210bcr/abl tyrosine kinase inhibitor and a potent inducer of myeloid cell death.
Adaphostin is a p210bcr/abl tyrosine kinase inhibitor displaying anti-proliferative activity in leukemia models, human prostate cancer cell line PC-3 and other cancer cell lines. Adaphostin is a potent inducer of myeloid cell death. Similarly to AG957, adaphostin appears to induce a degradation of WT and mutated Bcr/Abl.

Biological Activity

p210 bcr/abl tyrosine kinase inhibitor (IC 50 = 14 μ M). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 values range from 16.8 to 216.3 nM) in vitro . Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro .

References

[1] P A SVINGEN. Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro.[J]. Clinical Cancer Research, 2000, 6 1: 237-249.
[2] IOANNIS A AVRAMIS. In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines.[J]. Cancer Chemotherapy and Pharmacology, 2002, 50 6: 479-489. DOI:10.1007/s00280-002-0507-6.
[3] NADA ORSOLIC. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells[J]. Cancer Science, 2006, 97 9: 952-960. DOI:10.1111/j.1349-7006.2006.00269.x.
[4] JOYA CHANDRA. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells.[J]. Blood, 2003, 102 13: 4512-4519. DOI:10.1182/blood-2003-02-0562.
[5] KOUTAROH OKADA. Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.[J]. ACS Catalysis , 2019: 105-119. DOI:10.1016/j.ebiom.2019.01.019.

Adaphostin Preparation Products And Raw materials

Raw materials

Preparation Products

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Adaphostin Suppliers

Canada 1 China 47 India 1 United Kingdom 2 United States 7 USA 1 Global 59

J & K SCIENTIFIC LTD.

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241127-58-2, AdaphostinRelated Search:

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate

4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester

Adaphostin

Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester

1-Adamantyl 4-((2

5-Dihydroxybenzyl)Amino)Benzoate

1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate

Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML

Adamantan-1-yl 4-((2,5-dihydroxybenzyl)amino)benzoate

241127-58-2

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Pharmaceuticals