ChemicalBook > CAS DataBase List > 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
- Product Name
- 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
- CAS No.
- 241127-58-2
- Chemical Name
- 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
- Synonyms
- Adaphostin;1-Adamantyl 4-((2;5-Dihydroxybenzyl)Amino)Benzoate;1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate;1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate;4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester;Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
- CBNumber
- CB41456086
- Molecular Formula
- C24H27NO4
- Formula Weight
- 393.48
- MOL File
- 241127-58-2.mol
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1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Property
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1110
- Product name
- Adaphostin
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $92.2
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML1110
- Product name
- Adaphostin
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $317
- Updated
- 2022/05/15
TRC
- Product number
- A225020
- Product name
- Adaphostin
- Packaging
- 250mg
- Price
- $1320
- Updated
- 2021/12/16
Usbiological
- Product number
- 254543
- Product name
- Adaphostin
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
Usbiological
- Product number
- 001651
- Product name
- Adaphostin
- Packaging
- 25mg
- Price
- $460
- Updated
- 2021/12/16
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1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Chemical Properties,Usage,Production
Uses
Novel antitumor agent that induces apoptosis in tumor cells through inhibition of the tyrosine kinase BCR/ABL.
Biological Activity
p210 bcr/abl tyrosine kinase inhibitor (IC 50 = 14 μ M). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 values range from 16.8 to 216.3 nM) in vitro . Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro .
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Suppliers
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