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Guaiacol glycidyl ether

Product Name
Guaiacol glycidyl ether
CAS No.
2210-74-4
Chemical Name
Guaiacol glycidyl ether
Synonyms
2-[(2-Methoxyphenoxy)methyl]oxirane;Ranolazine USP Related Compound A;1-(2-Methoxyphenoxy) -2,3-Epoxy Propane;RZ-3;RZ-1;NSC 112256;NSC 133442;guajacol-glycidaether;GUAIACOL GLYCIDYL ETHER;Ranolazine Intermediate
CBNumber
CB4146647
Molecular Formula
C10H12O3
Formula Weight
180.2
MOL File
2210-74-4.mol
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Guaiacol glycidyl ether Property

Melting point:
33-36°C
Boiling point:
152-158℃
Density 
1.142±0.06 g/cm3(Predicted)
RTECS 
TZ3550000
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Chloroform, Methanol
form 
Solid
color 
Off-white
Water Solubility 
4.21g/L at 20℃
InChI
InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3
InChIKey
RJNVSQLNEALZLC-UHFFFAOYSA-N
SMILES
O1CC1COC1=CC=CC=C1OC
LogP
1.54 at 25℃
CAS DataBase Reference
2210-74-4(CAS DataBase Reference)
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Safety

HS Code 
29109000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TCI Chemical
Product number
G0416
Product name
Glycidyl 2-Methoxyphenyl Ether
Purity
>98.0%(GC)
Packaging
5g
Price
$49
Updated
2025/07/31
TCI Chemical
Product number
G0416
Product name
Glycidyl 2-Methoxyphenyl Ether
Purity
>98.0%(GC)
Packaging
25g
Price
$196
Updated
2025/07/31
TRC
Product number
M265700
Product name
2-[(2-Methoxyphenoxy)methyl]oxirane
Packaging
2g
Price
$145
Updated
2021/12/16
AK Scientific
Product number
J54647
Product name
2-[(2-Methoxyphenoxy)methyl]oxirane
Packaging
100g
Price
$150
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11683
Product name
2-[(2-Methoxyphenoxy)methyl]oxirane
Packaging
5G
Price
$1960
Updated
2021/12/16
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Guaiacol glycidyl ether Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

Ranolazine intermediate

Flammability and Explosibility

Non flammable

Synthesis

90-05-1

106-89-8

2210-74-4

To a round-bottomed flask was added 2.5 L of water followed by 80 g of sodium hydroxide and stirred until completely dissolved. Next, 500 g of guaiacol and 1.12 kg of 1-chloro-2,3-epoxypropane were added and the reaction was continuously stirred at 25-35°C for 5-6 hours. After completion of the reaction, the organic layer was separated. To the separated obtained epichlorohydrin layer was added 160 g of sodium hydroxide dissolved in 2.5 L of water and stirring was continued at 25-30 °C for 3-4 hours. The organic layer was again separated and the organic layer was washed with 150 g of sodium hydroxide dissolved in 1.5 L of water. Subsequently, the product layer was distilled at 90°C and 600-700 mmHg under vacuum to recover excess epichlorohydrin, resulting in 650-680 g of oily product. To this crude product was added 3.0 L of isopropanol, cooled to 0 °C and filtered to give 1-(2-methoxyphenoxy)-2,3-epoxypropane (3). Yield: 80%; purity >98%.

References

[1] Organic Process Research and Development, 2012, vol. 16, # 10, p. 1660 - 1664
[2] Medicinal Chemistry Research, 2004, vol. 13, # 8-9, p. 631 - 642
[3] Synthetic Communications, 1994, vol. 24, # 6, p. 833 - 838
[4] Tetrahedron, 2006, vol. 62, # 47, p. 10968 - 10979
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 26, p. 6641 - 6644

Guaiacol glycidyl ether Preparation Products And Raw materials

Raw materials

Guaiacol Epichlorohydrin

Preparation Products

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View Lastest Price from Guaiacol glycidyl ether manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Guaiacol glycidyl ether 2210-74-4
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Henan Aochuang Chemical Co.,Ltd.
Product
Guaiacol glycidyl ether 2210-74-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Hebei Ganmiao New material Technology Co., LTD
Product
Guaiacol glycidyl ether 2210-74-4
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-06

2210-74-4, Guaiacol glycidyl etherRelated Search:

BENZYL GLYCIDYL ETHER Isobutylene oxide Glycidyl acrylate Butyl glycidyl ether Ethylbenzene Methyl acetate Ethylene glycol diglycidyl ether PETROLEUM ETHER Allyl glycidyl ether Bensulfuron methyl Methylparaben 2-Methoxy-4-methylphenol 1,2,3-PROPANETRIOL GLYCIDYL ETHER (R)-Styrene oxide Propylene oxide DIGLYCIDYL ETHER Guaiacol Thiophanate-methyl

  • GUAIACOL GLYCIDYL ETHER
  • [(2-methoxyphenoxy)methyl]oxirane
  • 3-(O-METHOXYPHENOXY)-1,2-EPOXYPROPANE
  • O-METHOXY PHENYL CYCLOXYPROPYL ETHER
  • 1,2-epoxy-3-(o-methoxyphenoxy)-propan
  • 1,2-epoxy-3-(o-methoxyphenoxy)propane
  • 3-(2-Methoxphenoxy)-1,2-epoxypropane
  • Oxirane,2-[(2-Methoxyphenoxy)Methyl]-
  • Guaiacol glycidyl ether[(2-et hoxyhenoxy)Methyl]oxirane
  • Oxirane,2-[(2-Methoxyphenoxy)Methyl]- CAS NO.: 2210-74-4
  • 1-(2-Methoxyphenoxy)Methyl Oxirane
  • [(2-Methoxyphenoxy)Methyl]oxirane (GGE)
  • pharMaceutical internediate
  • Ranolazine Related CoMpound A
  • Guaiacol glycidyl ether [(2-Methoxyphenoxy)methyl]oxirane
  • Ranolazine Related Compound A (50 mg) ((+/-)-2-[(2-methoxyphenoxy)methyl]oxirane)
  • 1-(2-METHOXYPHENOXY)-2,3-EPXOYPROPANE
  • guajacol-glycidaether
  • [(o-methoxyphenoxy)methyl]oxirane
  • 1-(2-Mthoxyphenoxy)methyl oxirane
  • RZ-3
  • N-2,6-dimethylphenyl-2-chloro acetamide
  • RZ-1
  • 1,2-Epoxy-3-(2-Methoxyphenoxy)Propane
  • 3-(Dimethoxyphenoxy)-1,2-Propylene Epoxide
  • 1-[(2-methoxyphenoxy)methyl]oxirane oppure guaiacol glycidyl ether
  • 2-((2-METHOXYPHENOXY)METHYL)OXIRANE:95+%
  • 1-(2-Methoxyphenoxy) -2,3-Epoxy Propane
  • 1-(2,3-Epoxypropoxy)-2-methoxybenzene
  • 2-[(2-Methoxyphenoxy)methyl]oxirane
  • Glycidyl 2-Methoxyphenyl Ether
  • NSC 112256
  • NSC 133442
  • 1-(Glycidyloxy)-2-methoxybenzene
  • 1-(Oxiranylmethyloxy)-2-methoxybenzene
  • 2-[(o-Methoxyphenoxy)methyl]oxirane
  • Ranolazine Intermediate
  • 3-(2-Methoxyphenoxy)-1,2-epoxypropane
  • Guaiacol glycidyl ether（GGE）
  • Glycidyl2-MethoxyphenylEther&gt
  • Glycidyl2-methoxyphenylether,98%
  • Glycidyl Guaiacol Ether
  • Guaiacol glycidyl ether ISO 9001：2015 REACH
  • Reynolds azine impurity reference substance
  • Ranolazine USP Related Compound A
  • Guaifenesin Impurity-1/Ranolazine RC A
  • 2-(2-METHOXYPHNOXY)MEHYL OXIRANE
  • Ranolazine Related Compound A ((+/-)-2-[(2-methoxyphenoxy)methyl]oxirane) (1598755)
  • 1-methoxy-2-(oxiranylmethoxy)benzene
  • 2-[2-Methoxyphenoxy)methyl]Oxirane (MET)
  • 2-{[(2-methoxyphenyl)oxy]methyl}oxirane
  • Ranolazine Related Compound 4 1-(2-methoxyphenoxy)-2,3- epoxy propane
  • Ranolazine Related Compound A 2-[(2-Methoxyphenoxy)methyl]oxirane
  • Ranolazine Impurity 27 (Ranolazine USP Related Compound A)
  • [(2-Methoxyphenoxy)Methyl]Oxirane, 10 mM in DMSO
  • 2210-74-4
  • 210-74-4
  • INTERMEDIATESOFRANOLAZINE