ChemicalBook > CAS DataBase List > Bruceantinol

Bruceantinol

Product Name: Bruceantinol
CAS No.: 53729-52-5
Chemical Name: Bruceantinol
Synonyms: Bruceantinol;Bruceantinol, 10 mM in DMSO;Bruceantinol,inhibit,Inhibitor;Picras-3-en-21-oic acid, 15-[[(2E)-4-(acetyloxy)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-, methyl ester, (11β,12α,15β)-;Methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-4-(((E)-4-acetoxy-3,4-dimethylpent-2-enoyl)oxy)-1,2,9-trihydroxy-8,11a-dimethyl-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate
CBNumber: CB41469525
Molecular Formula: C30H38O13
Formula Weight: 606.61
MOL File: 53729-52-5.mol

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Bruceantinol Property

Boiling point:: 788.2±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 8.81±0.70(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AvaChem

Product number: 4466
Product name: Syringetin-3-O-rutinoside
Packaging: 1mg
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Updated: 2021/12/16

AvaChem

Product number: 4466
Product name: Syringetin-3-O-rutinoside
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Updated: 2021/12/16

AvaChem

Product number: 4466
Product name: Syringetin-3-O-rutinoside
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Updated: 2021/12/16

AvaChem

Product number: 4466
Product name: Syringetin-3-O-rutinoside
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Updated: 2021/12/16

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Bruceantinol Chemical Properties,Usage,Production

Uses

Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper[1]. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc[2].

Definition

ChEBI: Bruceantinol is a triterpenoid.

References

[1] Seung Mok Ryu, et al. Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper. Virus Res. 2017 Jan 2;227:49-56. DOI:10.1016/j.virusres.2016.09.013
[2] Ning Wei, et al. Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. Oncogene. 2019 Mar;38(10):1676-1687. DOI:10.1038/s41388-018-0547-y

Bruceantinol Preparation Products And Raw materials

Raw materials

Preparation Products

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53729-52-5, BruceantinolRelated Search:

Bruceantin

Bruceantinol

Picras-3-en-21-oic acid, 15-[[(2E)-4-(acetyloxy)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-, methyl ester, (11β,12α,15β)-

Methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-4-(((E)-4-acetoxy-3,4-dimethylpent-2-enoyl)oxy)-1,2,9-trihydroxy-8,11a-dimethyl-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate

Bruceantinol,inhibit,Inhibitor

Bruceantinol, 10 mM in DMSO

53729-52-5

C30H38O13