5-Hydroxy-6-nitropyridine-3-carboxylic acid
- Product Name
- 5-Hydroxy-6-nitropyridine-3-carboxylic acid
- CAS No.
- 59288-43-6
- Chemical Name
- 5-Hydroxy-6-nitropyridine-3-carboxylic acid
- Synonyms
- 5-hydroxy-6-nitronicotinic acid;6-Nitro-5-hydroxy Nicotinic Acid;3-Hydroxy-2-nitro-5-pyridinecarboxylic acid;5-Hydroxy-6-nitropyridine-3-carboxylic acid;5-Hydroxy-6-nitro-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 5-hydroxy-6-nitro-
- CBNumber
- CB41471289
- Molecular Formula
- C6H4N2O5
- Formula Weight
- 184.11
- MOL File
- 59288-43-6.mol
5-Hydroxy-6-nitropyridine-3-carboxylic acid Property
- Boiling point:
- 572.4±50.0 °C(Predicted)
- Density
- 1.745±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.53±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C6H4N2O5/c9-4-1-3(6(10)11)2-7-5(4)8(12)13/h1-2,9H,(H,10,11)
- InChIKey
- OODZZMDHMOPHHY-UHFFFAOYSA-N
- SMILES
- C1=NC([N+]([O-])=O)=C(O)C=C1C(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8822AB
- Product name
- 5-Hydroxy-6-nitronicotinicacid
- Packaging
- 1g
- Price
- $394
- Updated
- 2021/12/16
- Product number
- 121313
- Product name
- 5-Hydroxy-6-nitronicotinicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $425
- Updated
- 2021/12/16
- Product number
- CHM0386195
- Product name
- 5-HYDROXY-6-NITROPYRIDINE-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.5
- Updated
- 2021/12/16
- Product number
- 121313
- Product name
- 5-Hydroxy-6-nitronicotinicacid
- Purity
- 95%
- Packaging
- 500mg
- Price
- $276
- Updated
- 2021/12/16
- Product number
- 121313
- Product name
- 5-Hydroxy-6-nitronicotinicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $800
- Updated
- 2021/12/16
5-Hydroxy-6-nitropyridine-3-carboxylic acid Chemical Properties,Usage,Production
Uses
5-Hydroxy-6-nitropyridine-3-carboxylic acid is a 5-hydroxynicotinic acid (H948565) derivative used in the preparation of aminoheteroaryl protein kinase inhibitors.
Synthesis
27828-71-3
59288-43-6
1. Synthesis of 6-nitro-5-hydroxynicotinic acid (B2): 5-hydroxynicotinic acid (B1) (7.0 g, 50 mmol) was dissolved in concentrated H2SO4 and 9 mL of 90% fuming HNO3 (9 mL) was added slowly. The reaction mixture was transferred to a sealed tube and the reaction was stirred at 55-60°C for 4 days. Upon completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted with 50% NaOH solution to 3. Subsequently, the aqueous phase was saturated by the addition of MgSO4 and extracted with isopropanol (4 x 45 mL). The organic phases were combined and concentrated under reduced pressure to remove the isopropanol to give 5.93 g (64% yield) of B2 as a yellow solid. The mass spectrum (APCI) showed (M + H)+ of 185. 1H-NMR (DMSO-d6) δ 8.01 (d, 1H, Ar-H), 8.41 (d, 1H, Ar-H).
References
[1] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 45-46
[2] Patent: WO2006/21886, 2006, A1. Location in patent: Page/Page column 77
[3] Patent: WO2014/184234, 2014, A1. Location in patent: Page/Page column 55; 56
[4] Patent: CN105555786, 2016, A. Location in patent: Paragraph 0241
5-Hydroxy-6-nitropyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Hydroxy-6-nitropyridine-3-carboxylic acid manufacturers
- Product
- 5-Hydroxy-6-nitronicotinic acid 59288-43-6
- Price
- US $1500.00/g
- Min. Order
- 1g
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-04-23