2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)

Product Name: 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)
CAS No.: 235106-62-4
Chemical Name: 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)
Synonyms: MDT637;MDT-637;VP 14637;2,2'-[(4-Hydroxyphenyl)Methylene]bis[4-[[(5-Methyl-1H-tetrazol-1-yl)iMino]Methyl]phenol;Phenol, 2,2'-[(4-hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]-;2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL);2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL);(E)-2,2'-((4-Hydroxyphenyl)methylene)bis(4-((E)-(5-methyl-1H-tetrazol-1-ylimino)methyl)phenol)
CBNumber: CB41477009
Molecular Formula: C25H22N10O3
Formula Weight: 510.51
MOL File: 235106-62-4.mol

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2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Property

Melting point:: >225°C (dec.)
Boiling point:: 816.7±75.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Amber Vial, Refrigerator
solubility: Aqueous Base (Slightly), DMSO (Slightly)
form: Solid
pka: 7.67±0.50(Predicted)
color: White to Pale Beige
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17805
Product name: VP-14637
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 17805
Product name: VP-14637
Purity: ≥98%
Packaging: 5mg
Price: $211
Updated: 2024/03/01

Cayman Chemical

Product number: 17805
Product name: VP-14637
Purity: ≥98%
Packaging: 10mg
Price: $357
Updated: 2024/03/01

Usbiological

Product number: 022868
Product name: VP 14637
Packaging: 10mg
Price: $460
Updated: 2021/12/16

TRC

Product number: V785000
Product name: VP14637
Packaging: 10mg
Price: $185
Updated: 2021/12/16

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2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Chemical Properties,Usage,Production

Uses

Human respiratory syncytial virus (HRSV) is a major respiratory viral pathogen causing moderate to severe upper and lower respiratory tract infections in all ages and across a wide range of patient populations. VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms by binding into a small hydrophobic cavity in the inner core of F protein, interacting simultaneously with both the HR1 and HR2 domains.

Biological Activity

ec50: 5.4 nm for rsv fusionvp-14637 is an inhibitor of rsv.respiratory syncytial virus (rsv) is the leading cause of respiratory tract infections in humans. rsv f protein that mediates fusion of the viral envelope with the host cell membrane has become a target of anti-rsv treatment.

in vitro

previous study demonstrated that vp-14637 did not block rsv adsorption but inhibited rsv-induced cell-cell fusion and specifically bound to rsv-infected cells. vp-14637 was capable of specifically interacting with the rsv fusion protein. rsv variants resistant to vp-14637 were selected, in which no mutations arose in hr1, indicating a mechanism other than direct disruption of the heptad repeat interaction. the f proteins containing the resistance mutations exhibited greatly reduced binding of vp-14637 [1].

in vivo

in cotton rats, animals given as little as 126 microg/kg of vp-14637 by small droplet aerosol starting 1 day after experimental virus infection with either a rsv a or b subtype consistently had significantly lower mean pulmonary rsv titers and reduced histopathological findings than mock-treated animals or cotton rats given placebo. in addition, no cotton rat treated with vp14637 had any evident untoward responses [2].

References

[1] douglas, j. l.,panis, m.l.,ho, e., et al. inhibition of respiratory syncytial virus fusion by the small molecule vp-14637 via specific interactions with f protein. journal of virology 77(9), 5054-5064 (2003).
[2] wyde pr, laquerre s, chetty sn, gilbert be, nitz tj, pevear dc. antiviral efficacy of vp14637 against respiratory syncytial virus in vitro and in cotton rats following delivery by small droplet aerosol. antiviral res. 2005 oct;68(1):18-26.

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Preparation Products And Raw materials

Raw materials

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2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL) Suppliers

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235106-62-4, 2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)Related Search:

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)

VP 14637

2,2'-[(4-Hydroxyphenyl)Methylene]bis[4-[[(5-Methyl-1H-tetrazol-1-yl)iMino]Methyl]phenol

(E)-2,2'-((4-Hydroxyphenyl)methylene)bis(4-((E)-(5-methyl-1H-tetrazol-1-ylimino)methyl)phenol)

MDT637

MDT-637

Phenol, 2,2'-[(4-hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]-

2,2''-[(4-HYDROXYFENYL)METHYLEEN]BIS(4-{(E)-[(5-METHYL-1H-TETRAZOOL1-YL)IMINO]METHYL}FENOL)

235106-62-4

C25H22N10O3

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