6,4''-DIHYDROXYAURONE

Product Name: 6,4''-DIHYDROXYAURONE
CAS No.: 5786-54-9
Chemical Name: 6,4''-DIHYDROXYAURONE
Synonyms: NSC356828;(Z)-Hispidol;Hispidol, >98%;hispidol 98%MIN;6,4''-DIHYDROXYAURONE;Hispidol, 10 mM in DMSO;(Z)-6-Hydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one;3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)-;inhibit,Hispidol,TNF Receptor,Tumor Necrosis Factor Receptor,TNFR,Inhibitor;(2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one
CBNumber: CB41484708
Molecular Formula: C15H10O4
Formula Weight: 254.24
MOL File: 5786-54-9.mol

More

Less

6,4''-DIHYDROXYAURONE Property

Melting point:: 286-288 °C
Boiling point:: 523.8±50.0 °C(Predicted)
Density: 1.489±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
form: A solid
pka: 7.59±0.20(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FH45951
Product name: Hispidol
Packaging: 2mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH45951
Product name: Hispidol
Packaging: 5mg
Price: $300
Updated: 2021/12/16

DC Chemicals

Product number: DC10585
Product name: Hispidol
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC10585
Product name: Hispidol
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

More

Less

6,4''-DIHYDROXYAURONE Chemical Properties,Usage,Production

Uses

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM.

Definition

ChEBI: A hydroxyaurone that is aurone substituted by hydroxy groups at positions 6 and 4' respectively.

in vivo

The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner^[1].

References

[1] Kadayat TM, et al. Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. Eur J Med Chem. 2017 Sep 8;137:575-597. DOI:10.1016/j.ejmech.2017.06.018

6,4''-DIHYDROXYAURONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

6,4''-DIHYDROXYAURONE Suppliers

China 55 United Kingdom 2 United States 7 USA 1 Global 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

5786-54-9, 6,4''-DIHYDROXYAURONERelated Search:

NSC356828

Hispidol, >98%

(Z)-Hispidol

3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)-

inhibit,Hispidol,TNF Receptor,Tumor Necrosis Factor Receptor,TNFR,Inhibitor

6,4''-DIHYDROXYAURONE

(2Z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one

Hispidol, 10 mM in DMSO

(Z)-6-Hydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one

hispidol 98%MIN

5786-54-9

Aurones