2-CHLORO-4-PHENYLQUINAZOLINE
Uses- Product Name
- 2-CHLORO-4-PHENYLQUINAZOLINE
- CAS No.
- 29874-83-7
- Chemical Name
- 2-CHLORO-4-PHENYLQUINAZOLINE
- Synonyms
- quinazoL;oro-4-phenyL;2-CHLORO-4-PHENYLQUIZOLINE;2-CHLORO-4-PHENYLQUINAZOLIN;2-Chloro-4-phenylq inazollne;2-CHLORO-4-PHENYLQUINAZOLINE;Quinazoline,2-chloro-4-phenyl-;2-CHLORO-4-PHENYLQUINAZOLINE ISO 9001：2015 REACH
- CBNumber
- CB41490329
- Molecular Formula
- C14H9ClN2
- Formula Weight
- 240.69
- MOL File
- 29874-83-7.mol
2-CHLORO-4-PHENYLQUINAZOLINE Property
- Melting point:
- 113.0 to 117.0 °C
- Boiling point:
- 347.4±30.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 0.24±0.30(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C14H9ClN2/c15-14-16-12-9-5-4-8-11(12)13(17-14)10-6-2-1-3-7-10/h1-9H
- InChIKey
- SFKMVPQJJGJCMI-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=CC=C2)=C(C2=CC=CC=C2)N=C1Cl
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C3173
- Product name
- 2-Chloro-4-phenylquinazoline
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $80
- Updated
- 2025/07/31
- Product number
- C3173
- Product name
- 2-Chloro-4-phenylquinazoline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $275
- Updated
- 2025/07/31
- Product number
- C371395
- Product name
- 2-Chloro-4-phenylquinazoline
- Packaging
- 5g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 31150
- Product name
- 2-Chloro-4-phenylquinazoline,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $152.94
- Updated
- 2021/12/16
- Product number
- 135535
- Product name
- 2-Chloro-4-phenyl-quinazoline
- Purity
- 95%+
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
2-CHLORO-4-PHENYLQUINAZOLINE Chemical Properties,Usage,Production
Uses
2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.
Uses
2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.
Uses
2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).
References
[1] Patent: KR2017/10582, 2017, A. Location in patent: Paragraph 0251-0254
[2] Patent: KR2016/74426, 2016, A. Location in patent: Paragraph 0162; 0163; 0164; 0165
[3] Patent: KR2017/97450, 2017, A. Location in patent: Paragraph 0317-0319; 0337-0339
[4] Patent: WO2012/67425, 2012, A1. Location in patent: Page/Page column 39-40
[5] Patent: WO2012/36482, 2012, A1. Location in patent: Page/Page column 27-28
2-CHLORO-4-PHENYLQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-4-PHENYLQUINAZOLINE Suppliers
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View Lastest Price from 2-CHLORO-4-PHENYLQUINAZOLINE manufacturers
- Product
- 2-CHLORO-4-PHENYLQUINAZOLINE 29874-83-7
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 2-chloro-4-phenylquinazoline 29874-83-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500 kgs
- Release date
- 2024-07-08
- Product
- 2-Chloro-4-phenylquinazoline 29874-83-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30