4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE

Product Name: 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
CAS No.: 13414-95-4
Chemical Name: 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE
Synonyms: 6,7-DIHYDROBENZO[B]THIOPHEN-4(5H)-ONE;AKOS 92215;2H-thiochroMene;AKOS BBS-00000945;RARECHEM AK MA K003;6,7-Dihydrobenzothiophen-4-one;6,7-DIHYDRO-4-BENZO(B)THIOPHENE;TETRAHYDROBENZO(B)THIOPHEN-4-ONE;4-Oxotetrahydrobenzo(b)thiophene;6,7-DIHYDROBENZO[B]THIOPHEN-4-ONE
CBNumber: CB4149507
Molecular Formula: C8H8OS
Formula Weight: 152.21
MOL File: 13414-95-4.mol

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4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Property

Melting point:: 38-40 °C(lit.)
Boiling point:: 120 °C (10 mmHg)
Density: 1.245±0.06 g/cm3(Predicted)
refractive index: 1.5895-1.5915
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in chloroform.
form: <38°C Solid,>40°C Liquid
color: White to yellow
BRN: 112276
InChI: InChI=1S/C8H8OS/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2
InChIKey: GJEKNELSXNSYAQ-UHFFFAOYSA-N
SMILES: S1C2=C(C(=O)CCC2)C=C1
EPA Substance Registry System: Benzo[b]thiophen-4(5H)-one, 6,7-dihydro- (13414-95-4)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-24/25-36/37/39-26
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: K3603
Product name: 6,7-Dihydro-4-benzo[b]thiophenone
Purity: 98%
Packaging: 1g
Price: $40
Updated: 2023/01/07

Sigma-Aldrich

Product number: K3603
Product name: 6,7-Dihydro-4-benzo[b]thiophenone
Purity: 98%
Packaging: 10g
Price: $380
Updated: 2023/01/07

TCI Chemical

Product number: D5714
Product name: 6,7-Dihydro-4-benzo[b]thiophenone
Packaging: 1G
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: D5714
Product name: 6,7-Dihydro-4-benzo[b]thiophenone
Packaging: 5G
Price: $127
Updated: 2025/07/31

TRC

Product number: D448325
Product name: 6,7-Dihydrobenzo[b]thiophen-4-one
Packaging: 5g
Price: $155
Updated: 2021/12/16

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4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Chemical Properties,Usage,Production

Chemical Properties

white to yellow low melting solid or liquid after

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs and is also used in medicine.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 17, p. 87, 1980 DOI: 10.1002/jhet.5570170118

Synthesis

4653-11-6

13414-95-4

General procedure: 4-(2-Thienyl)butyric acid (0.75 mmol, 1.0 eq.), trifluoroacetic anhydride (TFAA, 2.25 mmol, 3 eq.), and trifluoroacetic acid (TFA, 0.8 mL) were added to a 10 mL glass reaction vial equipped with a screw cap. The reaction mixture was stirred at room temperature for 12 h. The reaction process was monitored by thin layer chromatography (TLC) or gas chromatography-mass spectrometry (GC-MS). Upon completion of the reaction, the solvent was removed under reduced pressure and the resulting residue was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate mixed system) to finally obtain the target product 6,7-dihydro-4-keto-5-benzothiophene (6a).

References

[1] Tetrahedron Letters, 2018, vol. 59, # 10, p. 869 - 872
[2] Tetrahedron Letters, 2003, vol. 44, # 21, p. 4007 - 4010
[3] Heterocycles, 1996, vol. 43, # 1, p. 127 - 131
[4] Patent: WO2010/76188, 2010, A1. Location in patent: Page/Page column 17-19
[5] Patent: WO2005/77932, 2005, A2. Location in patent: Page/Page column 208

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE Suppliers

Americas 1 Belgium 2 China 106 Europe 2 Germany 5 India 3 Japan 2 Slovakia 2 Switzerland 2 United Kingdom 3 United States 17 Global 145

skychemical Co.Ltd

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J & K SCIENTIFIC LTD.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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View Lastest Price from 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE manufacturers

Career Henan Chemical Co

Product: 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE 13414-95-4
Price: US $1.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 100kg
Release date: 2020-01-09

13414-95-4, 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENERelated Search:

2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE 2-PENTYL-6,7-DIHYDRO-5H-BENZO[B]THIOPHEN-4-ONE Tipentosin AKOS 91475 AKOS 91482 AKOS 91460 AKOS 91474 RARECHEM AK MA K052 AKOS 91481 AKOS 91178 5-AMINO-6,7-DIHYDRO-5H-BENZO[B]THIOPHEN-4-ONE SPECS AP-836/41220430 AKOS 91417 AKOS 91236 AKOS 91181 5,5-Dibromo-6,7-dihydro5H-benzo[b]thiophen-4-one

4-OXO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE

4-OXO-4,5,6,7-TETRAHYDROTHIANAPHTHENE

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE

RARECHEM AK MA K003

4-Oxotetrahydrobenzo(b)thiophene

4-Keto-4,5,6,7-tetrahydrothianaphthalene

4-Keto-4,5,6,7-tetrahydrothianaphthene, GC 97%

TETRAHYDROBENZO(B)THIOPHEN-4-ONE

6,7-DIHYDROBENZO[B]THIOPHEN-4-ONE

4-Keto-4,5,6,7-tetrahydrothianaphthene, 4-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene, 4-Oxo-4,5,6,7-tetrahydrothianaphthene

4,5,6,7-Tetrahydrobenzo[b]thiophene-4-one

4-Keto-4,5,6,7-tetrahydrothianaphthene,97%

6,7-Dihydrobenzothiophen-4-one

6,7-Dihydro-5H-benzo[b]thiophen-4-one

2H-thiochroMene

4,5,6,7-tetrahydro-1-benzothiophen-4-one

6,7-Dihydro-1-benzothiophen-4(5H)-one

4-Keto-4,5,6,7-tetrahydrothlanaphthene

Benzo[b]thiophen-4(5H)-one, 6,7-dihydro-

AKOS 92215

AKOS BBS-00000945

6,7-DIHYDRO-4-BENZO(B)THIOPHENE

6,7-DIHYDRO-4-BENZO[B]THIOPHENONE

6,7-DIHYDROBENZO[B]THIOPHEN-4(5H)-ONE

6,7-DIHYDROBENZO(B)THIOPHENE-4(5H)-ONE

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHEN

4-KETO-4,5,6,7-TETRAHYDROTHIANAPHTHENE ISO 9001：2015 REACH

4,5,6,7-Tetrahydro-4-oxo-benzo[b]thiophene

6,7-dihydro-5H-1-benzothiophen-4-one

6,7-Dihydro-4-benzo[<i>b</i>]thiophenone

13414-95-4

Building Blocks

Benzothiophenes

Heterocyclic Building Blocks

Heterocyclic Compounds