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2,2-DIFLUOROPENT-4-ENOIC ACID

Product Name
2,2-DIFLUOROPENT-4-ENOIC ACID
CAS No.
55039-89-9
Chemical Name
2,2-DIFLUOROPENT-4-ENOIC ACID
Synonyms
2,2-DIFLUOROPENT-4-ENOIC ACID;4-Pentenoic acid, 2,2-difluoro-;2,2-Difluoro-4-pentenoicacid,97%;2,2-Difluoropent-4-enoic acid,98% (stabilized with MEHQ)
CBNumber
CB41496972
Molecular Formula
C5H6F2O2
Formula Weight
136.1
MOL File
55039-89-9.mol
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2,2-DIFLUOROPENT-4-ENOIC ACID Property

Boiling point:
56-58°C/3mm
Density 
1.218
Flash point:
55℃
storage temp. 
2-8°C
pka
1.27±0.10(Predicted)
Appearance
Light brown to brown Liquid
Water Solubility 
Immiscible with water.
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Safety

Hazard Codes 
Xi
RIDADR 
3265
HazardClass 
IRRITANT
HazardClass 
8
PackingGroup 
Ⅱ
HS Code 
2916199590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
D456065
Product name
2,2-difluoropent-4-enoicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
024692
Product name
2,2-Difluoropent-4-enoic acid
Purity
97%
Packaging
1g
Price
$98
Updated
2021/12/16
Apolloscientific
Product number
PC6655
Product name
2,2-Difluoropent-4-enoicacid
Packaging
1g
Price
$138
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD104435
Product name
2,2-difluoropent-4-enoic Acid
Packaging
500mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD104435
Product name
2,2-difluoropent-4-enoic Acid
Packaging
1g
Price
$200
Updated
2021/12/16
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2,2-DIFLUOROPENT-4-ENOIC ACID Chemical Properties,Usage,Production

Uses

2,2-Difluoro-4-pentenoic acid is involved in the iodolactonization reaction to give the corresponding gamma- lactone, which is converted to prepare prepare 5-hydroxy-3,3-difluoropiperidine.

Synthesis

118337-48-7

55039-89-9

The general procedure for synthesizing 2,2-difluoro-4-pentenoic acid from allyl chlorodifluoroacetate is as follows: in Example 9, 100.0 g (0.59 mol) of allyl chlorodifluoroacetate, 42.2 g (0.65 mol) of zinc powder activated by the Fieser and Fieser methods, 96.7 g (0.88 mol) of trimethylchlorosilane and 400 mL of anhydrous acetonitrile were added to a glass autoclave and a trace amount of iodine was added as initiator. The reaction mixture was heated at 100 °C for 48 hours. Upon completion of the reaction, the precipitated zinc salt was removed by filtration and the filtrate was hydrolyzed with water. Subsequently, the reaction mixture was alkalized with 2N NaOH solution. The dark brown aqueous phase was extracted with pentane and then acidified with semi-concentrated hydrochloric acid before the product was extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated in a rotary evaporator and the residue was vacuum distilled. A final 59.4 g (74% yield) of the colorless oily product 2,2-difluoro-4-pentenoic acid was obtained with a boiling point of 73°-75°C/15.6 mbar.

References

[1] Chemical Research in Toxicology, 1995, vol. 8, # 5, p. 671 - 682
[2] Patent: US4892962, 1990, A

2,2-DIFLUOROPENT-4-ENOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-DIFLUOROPENT-4-ENOIC ACID Suppliers

China 53 India 1 Switzerland 1 United Kingdom 4 United States 4 Global 63
Carbosynth
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Apollo Scientific Ltd.
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Manchester Organics
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Fluorochem Ltd.
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enquiries@fluorochem.co.uk
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United Kingdom
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55039-89-9, 2,2-DIFLUOROPENT-4-ENOIC ACIDRelated Search:

5-CHLORO-2,2,3,3,4-PENTAFLUOROPENT-4-ENOIC ACID ETHYL 2,2,3,3,4,5-HEXAFLUOROPENT-4-ENOATE 2,2-DIFLUOROPENT-4-ENOIC ACID

  • 2,2-DIFLUOROPENT-4-ENOIC ACID
  • 4-Pentenoic acid, 2,2-difluoro-
  • 2,2-Difluoro-4-pentenoicacid,97%
  • 2,2-Difluoropent-4-enoic acid,98% (stabilized with MEHQ)
  • 55039-89-9