2,2-DIFLUOROPENT-4-ENOIC ACID
- Product Name
- 2,2-DIFLUOROPENT-4-ENOIC ACID
- CAS No.
- 55039-89-9
- Chemical Name
- 2,2-DIFLUOROPENT-4-ENOIC ACID
- Synonyms
- 2,2-DIFLUOROPENT-4-ENOIC ACID;4-Pentenoic acid, 2,2-difluoro-;2,2-Difluoro-4-pentenoicacid,97%;2,2-Difluoropent-4-enoic acid,98% (stabilized with MEHQ)
- CBNumber
- CB41496972
- Molecular Formula
- C5H6F2O2
- Formula Weight
- 136.1
- MOL File
- 55039-89-9.mol
2,2-DIFLUOROPENT-4-ENOIC ACID Property
- Boiling point:
- 56-58°C/3mm
- Density
- 1.218
- Flash point:
- 55℃
- storage temp.
- 2-8°C
- pka
- 1.27±0.10(Predicted)
- Appearance
- Light brown to brown Liquid
- Water Solubility
- Immiscible with water.
Safety
- Hazard Codes
- Xi
- RIDADR
- 3265
- HazardClass
- IRRITANT
- HazardClass
- 8
- PackingGroup
- Ⅱ
- HS Code
- 2916199590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D456065
- Product name
- 2,2-difluoropent-4-enoicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 024692
- Product name
- 2,2-Difluoropent-4-enoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- PC6655
- Product name
- 2,2-Difluoropent-4-enoicacid
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- FD104435
- Product name
- 2,2-difluoropent-4-enoic Acid
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD104435
- Product name
- 2,2-difluoropent-4-enoic Acid
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
2,2-DIFLUOROPENT-4-ENOIC ACID Chemical Properties,Usage,Production
Uses
2,2-Difluoro-4-pentenoic acid is involved in the iodolactonization reaction to give the corresponding gamma- lactone, which is converted to prepare prepare 5-hydroxy-3,3-difluoropiperidine.
Synthesis
118337-48-7
55039-89-9
The general procedure for synthesizing 2,2-difluoro-4-pentenoic acid from allyl chlorodifluoroacetate is as follows: in Example 9, 100.0 g (0.59 mol) of allyl chlorodifluoroacetate, 42.2 g (0.65 mol) of zinc powder activated by the Fieser and Fieser methods, 96.7 g (0.88 mol) of trimethylchlorosilane and 400 mL of anhydrous acetonitrile were added to a glass autoclave and a trace amount of iodine was added as initiator. The reaction mixture was heated at 100 °C for 48 hours. Upon completion of the reaction, the precipitated zinc salt was removed by filtration and the filtrate was hydrolyzed with water. Subsequently, the reaction mixture was alkalized with 2N NaOH solution. The dark brown aqueous phase was extracted with pentane and then acidified with semi-concentrated hydrochloric acid before the product was extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated in a rotary evaporator and the residue was vacuum distilled. A final 59.4 g (74% yield) of the colorless oily product 2,2-difluoro-4-pentenoic acid was obtained with a boiling point of 73°-75°C/15.6 mbar.
References
[1] Chemical Research in Toxicology, 1995, vol. 8, # 5, p. 671 - 682
[2] Patent: US4892962, 1990, A
2,2-DIFLUOROPENT-4-ENOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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