2-AMINO-4-CHLORO-BENZENEMETHANOL

Product Name: 2-AMINO-4-CHLORO-BENZENEMETHANOL
CAS No.: 37585-16-3
Chemical Name: 2-AMINO-4-CHLORO-BENZENEMETHANOL
Synonyms: 2-Amino-4-chlorobenzyl alcohol;2-AMINO-4-CHLORO-BENZENEMETHANOL;2-Amino-4-chlorobenzyl alcohol 98%;Benzenemethanol, 2-amino-4-chloro-;(2-AMino-4-chloro-phenyl)-Methanol
CBNumber: CB41497111
Molecular Formula: C7H8ClNO
Formula Weight: 157.6
MOL File: 37585-16-3.mol

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2-AMINO-4-CHLORO-BENZENEMETHANOL Property

Melting point:: 138-142°C
Boiling point:: 324.2±27.0 °C(Predicted)
Density: 1.341±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.01±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-43
Safety Statements: 26-36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 1662BB
Product name: (2-Amino-4-chlorophenyl)methanol
Packaging: 250mg
Price: $99
Updated: 2021/12/16

AK Scientific

Product number: 1662BB
Product name: (2-Amino-4-chlorophenyl)methanol
Packaging: 5g
Price: $232
Updated: 2021/12/16

AK Scientific

Product number: 1662BB
Product name: (2-Amino-4-chlorophenyl)methanol
Packaging: 10g
Price: $342
Updated: 2021/12/16

AK Scientific

Product number: 1662BB
Product name: (2-Amino-4-chlorophenyl)methanol
Packaging: 25g
Price: $628
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0142412
Product name: 2-AMINO-4-CHLORO-BENZENEMETHANOL
Purity: 95.00%
Packaging: 100MG
Price: $646.8
Updated: 2021/12/16

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2-AMINO-4-CHLORO-BENZENEMETHANOL Chemical Properties,Usage,Production

Synthesis

22996-18-5

37585-16-3

General procedure for the synthesis of (2-amino-4-chlorophenyl)methanol from 4-chloro-2-nitrobenzenemethanol: 4-chloro-2-nitrobenzenemethanol (1 g, 5.33 mmol, ALDRICH) and platinum(IV) oxide (100 mg, 0.44 mmol) were suspended in ethanol (100 mL) and hydrogenated for 1 hr at room temperature and 1300 mbar hydrogen pressure. . After completion of the reaction, the suspension was filtered, the filter cake was washed with ethanol, and the filtrates were combined and concentrated to dryness to give the crude product (2-amino-4-chlorophenyl)methanol as a light orange solid. The crude product was purified by rapid chromatography on silica gel, the eluent being a gradient of dichloromethane solution of 0 to 3% methanol. The target fraction was collected and the solvent was evaporated to dryness to give the pure product (2-amino-4-chlorophenyl)methanol (0.650 g, 77% yield) as a light orange solid. NMR hydrogen spectrum (DMSO-d6) data: δ 4.34 (d, 2H), 5.06 (t, 1H), 5.20 (s, 2H), 6.51 (dd, 1H), 6.64 (d, 1H), 7.05 (d, 1H).

References

[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 35, p. 10573 - 10576
[2] Angew. Chem., 2017, vol. 129, # 35, p. 10709 - 10712,4
[3] Synlett, 2017, vol. 28, # 14, p. 1724 - 1728
[4] Patent: WO2008/104754, 2008, A1. Location in patent: Page/Page column 178-179
[5] Journal of Medicinal Chemistry, 1993, vol. 36, # 22, p. 3397 - 3408

2-AMINO-4-CHLORO-BENZENEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4-CHLORO-BENZENEMETHANOL Suppliers

China 55 India 1 United States 5 Global 61

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37585-16-3, 2-AMINO-4-CHLORO-BENZENEMETHANOLRelated Search:

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2-AMINO-4-CHLORO-BENZENEMETHANOL

(2-AMino-4-chloro-phenyl)-Methanol

2-Amino-4-chlorobenzyl alcohol

Benzenemethanol, 2-amino-4-chloro-

2-Amino-4-chlorobenzyl alcohol 98%

37585-16-3