2,4-Dichloro-5,6-dimethylpyrimidine
- Product Name
- 2,4-Dichloro-5,6-dimethylpyrimidine
- CAS No.
- 1780-32-1
- Chemical Name
- 2,4-Dichloro-5,6-dimethylpyrimidine
- Synonyms
- 2,4-Dichloro-5,6-dimethylpyrimidine;PyriMidine, 2,4-dichloro-5,6-diMethyl-;2,4-Dichloro-5,6-dimethylpyrimidine ISO 9001：2015 REACH
- CBNumber
- CB41501252
- Molecular Formula
- C6H6Cl2N2
- Formula Weight
- 177.03
- MOL File
- 1780-32-1.mol
2,4-Dichloro-5,6-dimethylpyrimidine Property
- Melting point:
- 70-71 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 245.3±35.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.72±0.39(Predicted)
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D439693
- Product name
- 2,4-Dichloro-5,6-dimethylpyrimidine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D439693
- Product name
- 2,4-Dichloro-5,6-dimethylpyrimidine
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- W3886
- Product name
- 2,4-Dichloro-5,6-dimethylpyrimidine
- Packaging
- 250mg
- Price
- $107
- Updated
- 2021/12/16
- Product number
- OR926134
- Product name
- 2,4-Dichloro-5,6-dimethylpyrimidine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 119084
- Product name
- 2,4-Dichloro-5,6-dimethylpyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $144
- Updated
- 2021/12/16
2,4-Dichloro-5,6-dimethylpyrimidine Chemical Properties,Usage,Production
Synthesis
26305-13-5
1780-32-1
General procedure for the synthesis of 2,4-dichloro-5,6-dimethylpyrimidine from 5,6-dimethyluracil: A mixture of 5,6-dimethyluracil (4.00 g, 28.5 mmol), phosphorochloride (60 mL, 0.642 mol), and dimethylformamide (0.08 mL, 1.03 mmol) was heated and refluxed for 23 hours at 110 °C. Upon completion of the reaction, the reaction mixture was cooled to room temperature and evaporated. Toluene (80 mL) was added to the residue and the mixture was subsequently concentrated. Cold water (160 mL) containing ice was added to the residue and the mixture was extracted with chloroform (3 x 60 mL). The organic layers were combined, washed with brine (2 x 150 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give 2,4-dichloro-5,6-dimethylpyrimidine as a light yellow solid (4.37 g, 87% yield). The melting point of the product was 68-70 °C. 1H NMR (400 MHz, CDCl3) δ 2.55 (s, 3H), 2.34 (s, 3H). lRMS (ESI+) m/z 177.1.
References
[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0503
[2] Patent: WO2016/22460, 2016, A1. Location in patent: Page/Page column 140-141
[3] Patent: WO2017/66428, 2017, A1. Location in patent: Page/Page column 253
[4] Patent: WO2013/123401, 2013, A1. Location in patent: Page/Page column 40
[5] Nucleosides, Nucleotides and Nucleic Acids, 2004, vol. 23, # 11, p. 1707 - 1721
2,4-Dichloro-5,6-dimethylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-5,6-dimethylpyrimidine manufacturers
- Product
- 2,4-Dichloro-5,6-dimethylpyrimidine 1780-32-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- 2,4-Dichloro-5,6-dimethylpyrimidine 1780-32-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-03-23