ChemicalBook > CAS DataBase List > PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER

PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER

Product Name: PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER
CAS No.: 951626-95-2
Chemical Name: PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER
Synonyms: KML-98;KML-67;Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carb;ethyl 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine-2-carboxylate;4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate;ethyl 4-oxo-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-2-carboxylate;PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER
CBNumber: CB41502244
Molecular Formula: C9H11N3O3
Formula Weight: 209.2
MOL File: 951626-95-2.mol

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PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER Property

Boiling point:: 504.8±45.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.84±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E945968
Product name: Ethyl4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine-2-carboxylate
Packaging: 100mg
Price: $330
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0384522
Product name: ETHYL-4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $503.22
Updated: 2021/12/16

Matrix Scientific

Product number: 124249
Product name: Ethyl4-oxo-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrazine-2-carboxylate
Purity: 95+%
Packaging: 1g
Price: $924
Updated: 2021/12/16

AK Scientific

Product number: Z5395
Product name: Ethyl4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
Packaging: 5g
Price: $1281
Updated: 2021/12/16

Chemenu

Product number: CM126440
Product name: ethyl4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $89
Updated: 2021/12/16

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PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

1380507-24-3

951626-95-2

Diethyl 1-(3-tert-butoxycarbonylaminoethyl)-1H-pyrazole-3,5-dicarboxylate (2.4 g, 6.7 mmol) was dissolved in a dioxane solution (25 mL) of 4 N hydrochloric acid under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 1 h before being alkalized with saturated sodium carbonate solution and extracted with dichloromethane. The organic phase was separated, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and the solvent concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel as stationary phase, eluent dichloromethane/methanol solution containing 7 M ammonia, gradient from 0/100 to 5/95). The target fraction was collected and the solvent was removed under reduced pressure to afford ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (1.1 g, 79% yield) as a white solid. The molecular formula of the compound is C9H11N3O3 and the LCMS analysis resulted in a retention time of 0.49 min and a mass-to-charge ratio of m/z 210 [M+H]+ (refer to LCMS method 1).

References

[1] Patent: WO2012/78817, 2012, A1. Location in patent: Page/Page column 140
[2] Patent: WO2012/83224, 2012, A1. Location in patent: Page/Page column 266
[3] Patent: WO2013/192350, 2013, A1. Location in patent: Paragraph 00591
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 2, p. 429 - 434
[5] Patent: US2015/361081, 2015, A1. Location in patent: Paragraph 0480

PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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951626-95-2, PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTERRelated Search:

ethyl 4-hydroxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate ETHYL 5-ISOPROPYL-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZINE-6-CARBOXYLATE Pyrrolo[1,2-b]pyridazine-3-carboxylic acid, 1,4-dihydro-4-oxo-, ethyl ester (4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZIN-2-YL)METHANOL PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-A]PYRAZINE SALOR-INT L159913-1EA ETHYL 5-BENZYL-4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLATE 6,7-DIHYDRO-PYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE pyrazolo[1,5-a]pyridine-5-carboxylic acid pyrazolo[1,5-a]pyridin-6-amine PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE 3-AMinopyrazolo[1,5-a]pyriMidine TFA Pyrazolo[1,5-a]pyridin-4-ol ETHYL PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLATE Pyrazolo[1,5-a]pyridine-6-methanol methyl pyrazolo[1,5-a]pyrimidine-3-carboxylate

PYRAZOLO[1,5-A]PYRAZINE-2-CARBOXYLIC ACID, 4,5,6,7-TETRAHYDRO-4-OXO-, ETHYL ESTER

4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

ethyl 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine-2-carboxylate

ethyl 4-oxo-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-2-carboxylate

KML-67

KML-98

Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carb

951626-95-2