ChemicalBook > CAS DataBase List > 3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-

3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-

Product Name
3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-
CAS No.
76272-36-1
Chemical Name
3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-
Synonyms
8-benzyl-8-azabicyclo[3.2.1]octan-1-aMine;8-Benzyl-8-azabycyclo (3.2.1)octan-3-amine;Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine;exo-3-ami-8-benzyl-8-azabicyclo[3.2.1]octane;exo-8-Benzyl-8-azabicyclo[3.2.1]octan-3-aMine;8-Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine;exo-3-amino-8-benzyl-8-azabicyclo[3.2.1]octane;8-Benzyl-8-azabicyclo[3.2.1]octane-3-exo-amino;(exo-8-Benzyl-8-azabicyclo[3.2.1]oct-3-yl)aMine;(3-Exo)-8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamine
CBNumber
CB41504051
Molecular Formula
C14H20N2
Formula Weight
216.33
MOL File
76272-36-1.mol
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3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)- Property

Boiling point:
110-115 °C(Press: 0.05 Torr)
Density 
1.082±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
10.23±0.20(Predicted)
form 
Oil
color 
Clear Light yellow to Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B230760
Product name
Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine
Packaging
500mg
Price
$165
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18374
Product name
Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine
Packaging
50mg
Price
$254.5
Updated
2021/12/16
Matrix Scientific
Product number
073693
Product name
8-Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine
Purity
95+%
Packaging
250mg
Price
$324
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18374
Product name
Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine
Packaging
100mg
Price
$462
Updated
2021/12/16
AK Scientific
Product number
B731
Product name
8-Benzyl-8-azabicyclo[3.2.1]octane-3-exo-amine
Packaging
5g
Price
$525
Updated
2021/12/16
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3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)- Chemical Properties,Usage,Production

Uses

Intermediate in the preparation of CCR5 receptor antagonists, antibacterial agents and dopamine antagonists

Synthesis

76272-34-9

76272-36-1

General procedure for the synthesis of exo-8-benzyl-8-azabicyclo[3.2.1]octan-3-one oxime from 8-benzyl-8-azabicyclo[3.2.1]octan-3-amine:[105] 8-benzyl-8-azabicyclo[3.2.1]octan-3-one oxime (7.65 g, 33 mmol) was dissolved in 1-pentanol (130 mL) at 120 °C. Sodium metal (7.6 g, 0.33 mol, 10.0 eq.) was added in batches over 2 hours. The mixture was stirred and heated under reflux conditions for 5 hours, then cooled to 5°C. The reaction mixture was slowly acidified with 6 M HCl until the pH reached acidic, and then the aqueous phase was further extracted with 6 M HCl (3 x 100 mL). The aqueous layer was gradually alkalized to pH 10 by addition of 5 M NaOH. the resulting aqueous solution was extracted with EtOAc (3 × 100 mL). The organic extracts were combined, dried with MgSO4, filtered and concentrated in vacuum. The crude product was purified by column chromatography (5-10% MeOH/CH2Cl2) to afford pure exo-8-benzyl-8-azabicyclo[3.2.1]octan-3-amine as a solid (2.60 g, 36%).

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 11, p. 5020 - 5033
[2] Journal of Heterocyclic Chemistry, 1982, vol. 19, # 3, p. 485 - 488
[3] Patent: WO2008/63600, 2008, A2. Location in patent: Page/Page column 11-12; 26
[4] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 2, p. 133 - 137
[5] Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1906 - 1928

3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)- Suppliers

Canada 1 China 64 Czech Republic 1 Germany 1 India 2 United Kingdom 1 United States 7 Global 77
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View Lastest Price from 3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)- manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)- 76272-36-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-07
Shaanxi Dideu Medichem Co. Ltd
Product
8-Benzyl-8-azabicyclo[3.2.1]octane-3-exo-amino 76272-36-1
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KG
Release date
2019-12-30
Shaanxi Dideu Medichem Co. Ltd
Product
Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine 76272-36-1
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
100 tons
Release date
2019-12-26

76272-36-1, 3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-Related Search:

5-Pyrimidinecarboxamide, 2-amino-N-(8-(p-fluorobenzyl)-3-beta-nortropa nyl)-4-methoxy-, monomaleate 5-Pyrimidinecarboxamide, N-(8-benzyl-3-beta-nortropanyl)-2-ethyl-4-met hoxy- 5-Pyrimidinecarboxamide, 2-amino-N-(8-benzyl-3-beta-nortropanyl)-4-met hoxy- 2-Amino-4-methoxy-N-(8-(p-nitrobenzyl)-3-beta-nortropanyl)-5-pyrimidin ecarboxamide maleate 2-Amino-4-methoxy-N-(8-(o-methylbenzyl)-3-beta-nortropanyl)-5-pyrimidi necarboxamide 5-Pyrimidinecarboxamide, N-(8-benzyl-3-beta-nortropanyl)-2-(dimethylam ino)-4-ethoxy-, monomaleate 2-Amino-N-(8-(o-fluorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidi necarboxamide 5-Pyrimidinecarboxamide, 4-methoxy-N-(8-(phenylmethyl)-8-azabicyclo(3. 2.1)oct-3-yl)-, exo- 2-Amino-N-(8-benzyl-3-beta-nortropanyl)-4-ethoxy-5-pyrimidinecarboxami de maleate 5-Pyrimidinecarboxamide, N-(8-benzyl-3-beta-nortropanyl)-2-(dimethylam ino)-4-methoxy-, monomaleate 5-Pyrimidinecarboxamide, N-(8-benzyl-3-beta-nortropanyl)-4-ethoxy-2-et hyl- 2-Amino-N-(8-(m-chlorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidi necarboxamide exo-5-Bromo-2,3-dimethoxy-N-(8-(phenylmethyl)-8-azabicyclo(3.2.1)oct-3 -yl)benzamide 5-Pyrimidinecarboxamide, 4-ethoxy-N-(8-(phenylmethyl)-8-azabicyclo(3.2 .1)oct-3-yl)-, exo- 2-Amino-N-(8-(p-chlorobenzyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidi necarboxamide Benzamide, 4-amino-5-bromo-N-(8-((3,4-dichlorophenyl)methyl)-8-azabicy clo(3.2.1)oct-3-yl)-2-methoxy-, exo- Benzamide, 4-amino-5-bromo-N-(8-((4-ethylphenyl)methyl)-8-azabicyclo(3 .2.1)oct-3-yl)-2-methoxy-, exo- 2-Amino-4-methoxy-N-(8-(p-methylbenzyl)-3-beta-nortropanyl)-5-pyrimidi necarboxamide

  • exo-3-ami-8-benzyl-8-azabicyclo[3.2.1]octane
  • 3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-
  • 8-Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine
  • Benzyl-8-azabicyclo[3.2.1]octan-3-exo-amine
  • exo-3-amino-8-benzyl-8-azabicyclo[3.2.1]octane
  • 8-Azabicyclo[3.2.1]octan-3-amine,8-(phenylmethyl)-, (3-exo)-
  • 8-Benzyl-8-azabicyclo[3.2.1]octane-3-exo-amino
  • 8-benzyl-8-azabicyclo[3.2.1]octan-1-aMine
  • (3-exo-8-(PhenylMethyl)-8-azabicyclo[3.2.1]octan-3-aMine
  • (exo-8-Benzyl-8-azabicyclo[3.2.1]oct-3-yl)aMine
  • exo-8-Benzyl-8-azabicyclo[3.2.1]octan-3-aMine
  • (1R,3s,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-amine
  • 8-Benzyl-8-azabycyclo (3.2.1)octan-3-amine
  • (3-exo)-8-(Phenylmethyl)-8-azabicyclo [3.2.1]octan- 3-amine Fumarate salt
  • (1R,3r,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-amine
  • (3-Exo)-8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamine
  • exo-3-Amino-8-benzyl-8-azabicyclo[3.2.1]octane - [A14384]
  • Rel-(1r,3s,5s)-8-benzyl-8-azabicyclo[3.2.1]octan-3-amine
  • 76272-36-1
  • Amines
  • Aromatics
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