N-Benzyl-2-chloro-9H-purin-6-amine

Product Name: N-Benzyl-2-chloro-9H-purin-6-amine
CAS No.: 39639-47-9
Chemical Name: N-Benzyl-2-chloro-9H-purin-6-amine
Synonyms: 6-Benzylamino-2-chloropurine;N-BENZYL-2-CHLORO-7H-PURIN-6-AMINE;N-Benzyl-2-chloro-9H-purin-6-amine;2-Chloro-N-(phenylmethyl)-1H-purin-6-amine;9H-Purin-6-amine, 2-chloro-N-(phenylmethyl)-
CBNumber: CB41509304
Molecular Formula: C12H10ClN5
Formula Weight: 259.69
MOL File: 39639-47-9.mol

More

Less

N-Benzyl-2-chloro-9H-purin-6-amine Property

Melting point:: 239-241℃
Boiling point:: 407.7±55.0 °C(Predicted)
Density: 1.49
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform, DMSO, Ethyl Acetate
form: Solid
pka: 7.11±0.20(Predicted)
color: White

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: C368865
Product name: 2-Chloro-N-(phenylmethyl)-1H-purin-6-amine
Packaging: 100mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: 5206AB
Product name: N-Benzyl-2-chloro-9H-purin-6-amine
Packaging: 1g
Price: $205
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0143397
Product name: N-BENZYL-2-CHLORO-9H-PURIN-6-AMINE
Purity: 95.00%
Packaging: 1G
Price: $329.7
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 63658
Product name: 2-Chloro-N-(phenylmethyl)-1H-purin-6-amine
Packaging: 100mg
Price: $650
Updated: 2021/12/16

Ambeed

Product number: A199508
Product name: N-Benzyl-2-chloro-9H-purin-6-amine
Purity: 95%
Packaging: 250mg
Price: $46
Updated: 2021/12/16

More

Less

N-Benzyl-2-chloro-9H-purin-6-amine Chemical Properties,Usage,Production

Uses

2-Chloro-N-(phenylmethyl)-1H-purin-6-amine is an intermediate in the synthesis of Olomoucine (O567000), a purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest.

Synthesis

5451-40-1

100-46-9

39639-47-9

Synthesis of N-benzyl-2-chloro-9H-purin-6-amine (4): 2,6-dichloropurine (110 mg, 0.52 mmol) was suspended in n-butanol (3 mL) and benzylamine (57 mg, 0.52 mmol) and triethylamine (72 mg, 0.79 mmol) were added sequentially. The reaction mixture was heated at 60 °C with stirring for 15 min. Upon completion of the reaction, the precipitate was collected by filtration and washed sequentially with water (20 mL) and methanol (10 mL), followed by drying in air overnight to give off-white solid product 4 (130 mg, 95% yield). The product was characterized as follows: melting point 262 °C; EI/MS m/z (relative abundance): 259 (19, M+), 260 (14), 261 (17%), 106 (100), 91 (77); 1H NMR (400 MHz, DMSO-d6) δ 8.15 (s, 1H), 7.25-7.34 (m, 5H), 4.66 (d J = 6 Hz, 2H); 13C NMR (100 MHz, DMSO-d6) δ 155.0 (s), 153.1 (s), 150.7 (s), 140.2 (d, 1JC-H = 200 Hz), 139.6 (s), 128.5 (d, 2JC-H = 158 Hz), 127.5 (d, 3JC-H = 157 Hz), 127.0 (d, 4JC-H = 158 Hz), 118.1 (s), 43.4 (t, 2JC-H = 139 Hz).

References

[1] Organic Process Research and Development, 2009, vol. 13, # 3, p. 641 - 644
[2] Synthetic Communications, 2010, vol. 40, # 12, p. 1856 - 1866
[3] Patent: WO2012/51296, 2012, A2. Location in patent: Page/Page column 40
[4] Archiv der Pharmazie, 1999, vol. 332, # 6, p. 187 - 190
[5] Nucleosides, Nucleotides and Nucleic Acids, 2011, vol. 30, # 7-8, p. 503 - 511

N-Benzyl-2-chloro-9H-purin-6-amine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Benzyl-2-chloro-9H-purin-6-amine Suppliers

China 34 China Hong Kong 1 Europe 1 India 1 Switzerland 1 United States 2 Global 40

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Nanjing Baifuli Technology Co., Ltd.

Tel: 25-25-58740604 15951658055
Fax: +86-25-58356858
Email: sales@unisyn.cn
Country: China
ProdList: 591
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Tcichem, Inc.

Tel: 13918644899
Fax: -
Email: tianchong009@hotmail.com
Country: China
ProdList: 1818
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4995
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Amel Pharmatech Corporation

Tel: 027-888-4366503
Fax: 888-502-1736
Email: sales@amelpharmatech.com
Country: China
ProdList: 5000
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002 18367600069;
Email: zhejia01@163.com
Country: China
ProdList: 8887
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 6762
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd

Tel: 13005928603
Email: 211017228@qq.com
Country: China
ProdList: 8278
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-81145305 17791533577
Email: 1021@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9763
Advantage: 58

nanjing

Tel: 13376082704 13376084917;
Email: 3930959291@qq.com
Country: China
ProdList: 2079
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Shanghai Likai Chemical Technology Co., Ltd.

Tel: 16628776521
Email: 517680175@qq.com
Country: China
ProdList: 2887
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Wuhan Jingkang en Biomedical Technology Co., Ltd

Tel: +8613720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5221
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

39639-47-9, N-Benzyl-2-chloro-9H-purin-6-amineRelated Search:

1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE 6-benzylaminopurine hydrochloride N-BENZYL-N-(2-CHLOROPYRIMIDIN-4-YL)AMINE 2-CHLORO-N-METHYL-9H-PURIN-6-AMINE N-BENZYL-2-CHLORO-9-ISOPROPYL-9H-PURIN-6-AMINE N-Benzyl-2-chloro-9H-purin-6-amine

N-Benzyl-2-chloro-9H-purin-6-amine

2-Chloro-N-(phenylmethyl)-1H-purin-6-amine

6-Benzylamino-2-chloropurine

N-BENZYL-2-CHLORO-7H-PURIN-6-AMINE

9H-Purin-6-amine, 2-chloro-N-(phenylmethyl)-

39639-47-9