3-bromo-5-nitro-1H-indole
- Product Name
- 3-bromo-5-nitro-1H-indole
- CAS No.
- 525593-33-3
- Chemical Name
- 3-bromo-5-nitro-1H-indole
- Synonyms
- 3-Bromo-5-nitroindole;3-bromo-5-nitro-1H-indole;1H-Indole, 3-bromo-5-nitro-
- CBNumber
- CB41509359
- Molecular Formula
- C8H5BrN2O2
- Formula Weight
- 241.04
- MOL File
- 525593-33-3.mol
3-bromo-5-nitro-1H-indole Property
- Melting point:
- 191-194 °C
- Boiling point:
- 417.6±25.0 °C(Predicted)
- Density
- 1.855
- storage temp.
- 2-8°C
- pka
- 13.58±0.30(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B697995
- Product name
- 3-Bromo-5-nitro-1h-indole
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FB152557
- Product name
- 3-Bromo-5-nitro-1H-indole
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FB152557
- Product name
- 3-Bromo-5-nitro-1H-indole
- Packaging
- 10mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- FB152557
- Product name
- 3-Bromo-5-nitro-1H-indole
- Packaging
- 25mg
- Price
- $405
- Updated
- 2021/12/16
- Product number
- V6390
- Product name
- 3-Bromo-5-nitro-1h-indole
- Packaging
- 10g
- Price
- $498
- Updated
- 2021/12/16
3-bromo-5-nitro-1H-indole Chemical Properties,Usage,Production
Synthesis
6146-52-7
525593-33-3
Step A: A solution of pyridinium bromide (10.99 g, 34.3 mmol) in pyridine (200 mL) was slowly added dropwise to a solution of pyridinium bromide (10.99 g, 34.3 mmol) in pyridine (200 mL) of 5-nitroindole (5.00 g, 30.8 mmol) at -40 °C and under nitrogen protection. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 5 minutes. Subsequently, the reaction mixture was diluted with water (200 mL) at 0 °C and extracted with ether (200 mL). The organic layer was washed sequentially with 6 M hydrochloric acid (300 mL), 5% sodium bicarbonate solution (300 mL) and saturated saline (300 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give 3-bromo-5-nitroindole as a yellow powder with 80% purity containing 20% 5-nitroindole (6.80 g, 74% yield).
References
[1] Tetrahedron Letters, 2003, vol. 44, # 20, p. 3927 - 3930
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 17, p. 5965 - 5980
[3] RSC Advances, 2016, vol. 6, # 93, p. 90031 - 90034
[4] Tetrahedron Letters, 2015, vol. 56, # 9, p. 1096 - 1098
[5] Patent: WO2006/19831, 2006, A1. Location in patent: Page/Page column 415
3-bromo-5-nitro-1H-indole Preparation Products And Raw materials
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