1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER
- Product Name
- 1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER
- CAS No.
- 10250-59-6
- Chemical Name
- 1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER
- Synonyms
- 1,3-diMethyl-, Methyl ester;methyl 2,5-dimethylpyrazole-3-carboxylate;methyl 1,3-dimethylpyrazole-5-carboxylate;Methyl 1,3-dimethyl-1H-pyrazol-5-carboxylate;Methyl 1,3-diMethyl-1H-pyrazole-5-carboxylate;Methyl 2,5-dimethyl-2H-pyrazole-3-carboxylate;Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate;Methyl 1,3-Dimethyl-1H-Pyrazole-5-Carboxylate(WXC00828);2,5-dimethyl-2H-pyrazole-3-carboxylic acid methyl ester;1,3-Dimethyl-1H-pyrazole-5-carboxylic acid methyl ester
- CBNumber
- CB41511745
- Molecular Formula
- C7H10N2O2
- Formula Weight
- 154.17
- MOL File
- 10250-59-6.mol
1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER Property
- Boiling point:
- 242.0±20.0 °C(Predicted)
- Density
- 1.150 g/mL at 25 °C
- refractive index
- n20/D1.491
- Flash point:
- 78℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- liquid
- pka
- 0.94±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 732664
- Product name
- Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate
- Packaging
- 250mg
- Price
- $115
- Updated
- 2023/01/07
- Product number
- M303798
- Product name
- Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CHM0392770
- Product name
- Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.07
- Updated
- 2021/12/16
- Product number
- W9909
- Product name
- Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate
- Packaging
- 5g
- Price
- $548
- Updated
- 2021/12/16
- Product number
- OR925621
- Product name
- Methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER Chemical Properties,Usage,Production
Uses
Methyl 1,3-Dimethyl-1H-pyrazole-5-carboxylate is used as a reactant in the preparation of pyrazolyl acrylonitrile derivatives as acaricides.
Synthesis
25016-17-5
77-78-1
10250-59-6
1. dissolve methyl 5-methyl-1H-pyrazole-3-carboxylate (6.8 kg) in N,N-dimethylformamide (DMF, 8 L). 2. dimethyl sulfate (6.0 L) was slowly added dropwise over a period of 3 h. The rate of dropwise acceleration was controlled to maintain the reaction temperature at no more than 90°C. 3. After completion of the dropwise addition, the reaction mixture was heated and stirred at 80 °C for 18 hours. 4. After completion of the reaction, the mixture was cooled to room temperature, ice (3.4 kg) was added and further cooled in an ice bath. 5. 28% aqueous ammonium hydroxide solution (8.6 L) was slowly added to the reaction mixture over a period of 3 hours. 6. The resulting mixture was stirred for 18 hours and then diluted with ethyl acetate (12 L) and water (16 L), extracted and the organic layer was separated. 7. The organic layer was washed with water (4 L), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product of methyl 1,3-dimethyl-1H-pyrazole-5-carboxylate (5.14 kg, yield 69%, HPLC purity >90%). 8. The crude product was used directly in the subsequent reaction without further purification.
References
[1] Patent: WO2006/48761, 2006, A2. Location in patent: Page/Page column 33
[2] Journal of Agricultural and Food Chemistry, 2016, vol. 64, # 51, p. 9586 - 9591
1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
1H-PRRAZOLE-5-CARBOXYLIC ACID ,1,3-DIMETHYL METHYL ESTER Suppliers
- Tel
- 025-85760892 13376080562
- Fax
- 025-85766769
- sales@habotech.com
- Country
- China
- ProdList
- 885
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-56491756 13512199871
- 2819742715@qq.com
- Country
- China
- ProdList
- 4001
- Advantage
- 55
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39967
- Advantage
- 60
- Tel
- 18086832706
- Fax
- 028-89642128
- phakzjtxs@phak.cn
- Country
- China
- ProdList
- 138
- Advantage
- 58
- Tel
- 18040571231/1402788087
- Fax
- sales@chemduro.com
- Country
- China
- ProdList
- 1973
- Advantage
- 58
- Tel
- 0731-88827538 15873153880
- Fax
- 0731-88827238
- luxingbc@126.com
- Country
- China
- ProdList
- 2000
- Advantage
- 65
- Tel
- 025-025-52700520 18914499889
- Fax
- 025-52700520
- sales@yfbiotech.com
- Country
- China
- ProdList
- 495
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80