tert-Butyl 2-methylcarbazate

Product Name: tert-Butyl 2-methylcarbazate
CAS No.: 21075-83-2
Chemical Name: tert-Butyl 2-methylcarbazate
Synonyms: 1-Boc-1-methyL;Boc-1-Methylhydrazine;1-Boc-1-methylhydrazine;N-Boc-N-methylhydrazine;1-Boc-1-Methylhydrazine 97%;tert-Butyl 2-methylcarbazate;tert-Butyl 2-Methylcarbazate >1-Carbo-tert-butoxy-1-methylhydrazine;Tert-butyl N-amino-N-methyl-carbamate;2-Methylcarbazic Acid tert-Butyl Ester
CBNumber: CB41511826
Molecular Formula: C6H14N2O2
Formula Weight: 146.19
MOL File: 21075-83-2.mol

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tert-Butyl 2-methylcarbazate Property

Boiling point:: 186℃
Density: 0.985 g/mL at 25 °C
refractive index: n20/D 1.436
Flash point:: 71 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
pka: 3.28±0.10(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C6H14N2O2/c1-6(2,3)10-5(9)8(4)7/h7H2,1-4H3
InChIKey: IHMQNZFRFVYNDS-UHFFFAOYSA-N
SMILES: N(C(OC(C)(C)C)=O)(C)N

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 3
HS Code: 29242990
Storage Class: 10 - Combustible liquids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 699101
Product name: 1-Boc-1-methylhydrazine
Purity: 97%
Packaging: 5g
Price: $84.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 699101
Product name: 1-Boc-1-methylhydrazine
Purity: 97%
Packaging: 25g
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: B3998
Product name: tert-Butyl 2-Methylcarbazate
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $67
Updated: 2025/07/31

TCI Chemical

Product number: B3998
Product name: tert-Butyl 2-Methylcarbazate
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $220
Updated: 2025/07/31

Usbiological

Product number: 467080
Product name: tert-Butyl 1-Methylhydrazinecarboxylate
Packaging: 1g
Price: $403
Updated: 2021/12/16

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tert-Butyl 2-methylcarbazate Chemical Properties,Usage,Production

Uses

tert-Butyl 1-Methylhydrazinecarboxylate is a reactant in the synthesis of the hydrazide of (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane, the lead structure of the irreversible cathepsin C inhibitor.

Synthesis

24424-99-5

60-34-4

21075-83-2

Methylhydrazine (7) (26 g, 564 mmol) and sodium hydroxide (23 g, 575 mmol) were dissolved in methanol (500 mL). A solution of di-tert-butyl dicarbonate (123 g, 564 mmol) in methanol (500 mL) was added slowly and dropwise to this solution over a period of 2 h at 0°C. The reaction mixture was stirred at room temperature. The reaction mixture was stirred at room temperature for 2 h. The insoluble material was removed by filtration through diatomaceous earth. The filtrate was concentrated under reduced pressure and the oily residue obtained was neutralized with aqueous ammonium chloride. Subsequently, the aqueous phase was extracted with dichloromethane, the organic phase was dried with anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to afford 1-tert-butoxycarbonyl-1-methylhydrazine (8) (79 g, 97% yield). The product was characterized by 1H NMR (CDCl3): δ 4.06 (br, 2H), 3.05 (s, 3H), 1.47 (s, 9H); IR (pure) νmax 1694, 1365, 1154 cm-1.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 14, p. 2413 - 2418
[2] Chirality, 2013, vol. 25, # 6, p. 341 - 349
[3] Journal of Antibiotics, 1993, vol. 46, # 8, p. 1279 - 1288
[4] Patent: US5275816, 1994, A
[5] Bioorganic Chemistry, 2010, vol. 38, # 5, p. 229 - 233

tert-Butyl 2-methylcarbazate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 2-methylcarbazate Suppliers

Americas 1 Canada 1 China 129 Europe 1 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 10 Global 147

Sci General Material & Chemical Ltd

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Energy Chemical

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Capot Chemical Co., Ltd

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View Lastest Price from tert-Butyl 2-methylcarbazate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-Butyl 2-methylcarbazate 21075-83-2
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Boc-1-methylhydrazine 21075-83-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: METHYL TERT BUTYL CARBAZATE OR CEP 11841 21075-83-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

21075-83-2, tert-Butyl 2-methylcarbazateRelated Search:

METHYL TERT BUTYL CARBAZATE OR CEP 11841

1-Boc-1-methylhydrazine

2-Methylcarbazic acid tert-butyl ester, N-(tert-Butoxycarbonyl)-N-methylhydrazine, N-Boc-N-methylhydrazine

1,1-Dimethylethyl 1-methylhydrazinecarboxylate

1-Carbo-tert-butoxy-1-methylhydrazine

N-(tert-Butoxycarbonyl)-N-methylhydrazine

N-Boc-N-methylhydrazine

N-Methylhydrazinecarboxylic acid tert-butyl ester

tert-Butyl 1-methylhydrazinecarboxylate

tert-Butyl 2-methylcarbazate

2-Methyl-2-propanyl 1-Methylhydrazinecarboxylate

1-Boc-1-Methylhydrazine 97%

1-Methyl-1-tert-butoxycarbonylhydrazine

Boc-1-Methylhydrazine

2-Methylcarbazic Acid tert-Butyl Ester

Hydrazinecarboxylic acid, 1-methyl-, 1,1-dimethylethylester

tert-Butyl 2-Methylcarbazate &gt

1-Boc-1-methyL

Tert-butyl N-amino-N-methyl-carbamate

1-tert-Butoxycarbonyl-1-methylhydrazine

Hydrazinecarboxylic acid, 1-methyl-, 1,1-dimethylethyl ester (9CI, ACI)

1-methyl-Hydrazinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI)

1-Methylhydrazinecarboxylic acid tert-butyl ester

21075-83-2