methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate
- Product Name
- methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate
- CAS No.
- 872624-53-8
- Chemical Name
- methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate
- Synonyms
- methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate;2-AMino-5-Methyl-4-trifluoroMethyl-benzoic acid Methyl ester;Benzoic acid, 2-aMino-5-Methyl-4-(trifluoroMethyl)-, Methyl ester;2-amino-5-methyl-4-(trifluoromethyl)-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 2-amino-5-methyl-4-(trifluoromethyl)-, methyl ester (9CI, ACI)
- CBNumber
- CB41512368
- Molecular Formula
- C10H10F3NO2
- Formula Weight
- 233.19
- MOL File
- 872624-53-8.mol
methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate Property
- Boiling point:
- 285.8±40.0 °C(Predicted)
- Density
- 1.299±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.38±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- M331715
- Product name
- Methyl2-Amino-5-methyl-4-(trifluoromethyl)benzoate
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- HCH0369144
- Product name
- METHYL-2-AMINO-5-METHYL-4-(TRIFLUOROMETHYL)BENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.72
- Updated
- 2021/12/16
- Product number
- 126117
- Product name
- Methyl2-amino-5-methyl-4-(trifluoromethyl)benzoate
- Purity
- >95%
- Packaging
- 1g
- Price
- $864
- Updated
- 2021/12/16
- Product number
- A333132
- Product name
- Methyl2-amino-5-methyl-4-(trifluoromethyl)benzoate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $36
- Updated
- 2021/12/16
- Product number
- A333132
- Product name
- Methyl2-amino-5-methyl-4-(trifluoromethyl)benzoate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $53
- Updated
- 2021/12/16
methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate Chemical Properties,Usage,Production
Synthesis
872624-52-7
13061-96-6
872624-53-8
Step 4: Preparation of methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate To a solution of methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate (121 g, 351 mmol) in anhydrous 1,4-dioxane (2.5 L) under nitrogen protection was added sequentially cesium fluoride (184.3 g, 1.21 mol), methylboronic acid (63.7 g, 1.05 mol, 3 molar equivalents), and bis(diphenylphosphinoferrocene)palladium chloride (II ) (27.83 g, 35.1 mmol). The reaction mixture was heated and stirred at 80 °C for 3 hours. Upon completion of the reaction, which was cooled to room temperature, the reaction solution was partitioned between ethyl acetate (2.5 L) and water (2.5 L) and filtered through a Celite pad to remove the fine black suspension. The organic phase was separated and the aqueous phase was extracted with ethyl acetate (2 x 100 mL). The organic phases were combined, washed with brine (1 L) and dried over anhydrous magnesium sulfate. After filtration, it was concentrated under reduced pressure (45°C) to obtain a red oil. Purification by silica gel column chromatography with isohexane/ethyl acetate (9:1) as eluent gave methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate (75.25 g, 92% yield) as a light yellow crystalline solid.
References
[1] Patent: WO2006/2342, 2006, A1. Location in patent: Page/Page column 56-57
methyl 2-amino-5-methyl-4-(trifluoromethyl)benzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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