1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
- Product Name
- 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
- CAS No.
- 374794-96-4
- Chemical Name
- 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
- Synonyms
- 8-Boc-2-oxa-8-azaspiro[4.5]decane;2-Oxa-8-azaspiro[4.5]decane-8-carboxylicacid;tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate;1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate;2-Oxa-8-azaspiro[4.5]decane-8-CARBOXYLIC ACID TERT-BUTYL ESTER;2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester
- CBNumber
- CB41512434
- Molecular Formula
- C13H23NO3
- Formula Weight
- 241.33
- MOL File
- 374794-96-4.mol
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Property
- Boiling point:
- 333.5±35.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -0.77±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P000389233
- Product name
- tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $41
- Updated
- 2021/12/16
- Product number
- P000389233
- Product name
- tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- 9240CZ
- Product name
- Tert-butyl2-oxa-8-azaspiro[4.5]decane-8-carboxylate
- Packaging
- 250mg
- Price
- $141
- Updated
- 2021/12/16
- Product number
- P000389233
- Product name
- tert-Butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
- Product number
- CHM0152468
- Product name
- 1,1-DIMETHYLETHYL-2-OXA-8-AZASPIRO[4.5]DECANE-8-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.13
- Updated
- 2021/12/16
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical Properties,Usage,Production
Synthesis
236406-38-5
374794-96-4
General procedure for the synthesis of tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate from 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester: A solution of diethyl azodicarboxylate (183 μL, 1.16 mmol) of tetrahydrofuran (0.5 mL) was slowly added dropwise to a stirring 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylic acid tert-butyl ester (250 mg, 0.96 mmol) at 0 °C. tert-butyl 4-(hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate (250 mg, 0.96 mmol) and triphenylphosphine (303 mg, 1.16 mmol) solution in tetrahydrofuran (10 mL) under stirring. The reaction mixture was stirred at 0 °C for 90 min, followed by stirring at room temperature overnight. Afterwards, the mixture was cooled to 0-20 °C and additional triphenylphosphine (126 mg, 0.48 mmol) and diethyl azodicarboxylate (76 μL, 0.48 mmol) were added. The mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was purified by fast column chromatography on silica gel using isohexane/ethyl acetate (80:20) as eluent to afford tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate as a colorless oil (150 mg, 65% yield). Mass spectrum (electrospray positive ion mode) m/z: 186 ([M+1-C4H8]+).
References
[1] Patent: US2003/225059, 2003, A1. Location in patent: Page 27
[2] Patent: US2003/236250, 2003, A1. Location in patent: Page 30
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 13, p. 1759 - 1762
1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials
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View Lastest Price from 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate manufacturers
- Product
- 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate 374794-96-4
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-26