ETHYL 4-NITRO-L-PHENYLALANINE

Product Name: ETHYL 4-NITRO-L-PHENYLALANINE
CAS No.: 34276-53-4
Chemical Name: ETHYL 4-NITRO-L-PHENYLALANINE
Synonyms: 4-NO2-Phe-Oet;4-NO2-Phe-Oet-OH;ETHYL 4-NITRO-L-PHENYLALANINE;Ethyl 4-nitro-L-phenylalanine,95%;p-Nitro-L-phenylalanine ethyl ester;L-Phenylalanine, 4-nitro-, ethyl ester;ETHYL 4-NITRO-L-PHENYLALANINE USP/EP/BP;(S)-Ethyl 2-amino-3-(4-nitrophenyl)propanoate
CBNumber: CB41519488
Molecular Formula: C11H14N2O4
Formula Weight: 238.24
MOL File: 34276-53-4.mol

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ETHYL 4-NITRO-L-PHENYLALANINE Property

Boiling point:: 372.1±27.0 °C(Predicted)
Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka: 6.62±0.33(Predicted)
Appearance: Yellow to orange Solid
optical activity: Consistent with structure

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS35581
Product name: Ethyl 4-nitro-L-phenylalanine
Purity: 95+%
Packaging: 1g
Price: $44
Updated: 2021/12/16

Matrix Scientific

Product number: 126432
Product name: Ethyl4-nitro-L-phenylalanine
Purity: >95%
Packaging: 1g
Price: $72
Updated: 2021/12/16

Activate Scientific

Product number: AS35581
Product name: Ethyl 4-nitro-L-phenylalanine
Purity: 95+%
Packaging: 5G
Price: $108
Updated: 2021/12/16

Matrix Scientific

Product number: 126432
Product name: Ethyl4-nitro-L-phenylalanine
Purity: >95%
Packaging: 5g
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: W5577
Product name: Ethyl4-nitro-L-phenylalanine
Packaging: 5g
Price: $284
Updated: 2021/12/16

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ETHYL 4-NITRO-L-PHENYLALANINE Chemical Properties,Usage,Production

Synthesis

58816-66-3

34276-53-4

GENERAL STEPS: To a stirred mixed solution of ethyl (S)-2-amino-3-(4-nitrophenyl)propanoate hydrochloride (23.0 g, CAS No. 58816-66-3) in dichloromethane (230 mL) and water (230 mL) was slowly added 46-48% sodium hydroxide solution (7.7 g, 1.1 eq.). The organic and aqueous layers were separated and the aqueous phase was extracted with dichloromethane (100 mL). The combined dichloromethane layers were washed sequentially with water (100 mL) and saturated brine (100 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give ethyl (S)-2-amino-3-(4-nitrophenyl)propionate in quantitative yield. The resulting free nitro ester was dissolved in fresh dichloromethane (120 mL), spiro[3,5]nonane-1,3-dione (12.9 g, CAS No. 455264-97-8) [Ref: Wasserman, H.H. et al., J. Org. Chem., 38, 1451-1455 (1973)] was added, and the reaction was stirred. After 16 h, the completion of the reaction was confirmed by HPLC monitoring. The reaction mixture was diluted with dichloromethane (120 mL), washed sequentially with 11% sodium bicarbonate solution (100 mL), saturated brine (100 mL) and then dried over anhydrous magnesium sulfate. After removing the solvent under reduced pressure, ethyl (S)-2-amino-3-(4-nitrophenyl)propionate was obtained in quantitative yield (32.4 g as a slowly crystallizing viscous oil; melting point 120 °C). NMR hydrogen spectrum (DMSO-d6) δ: 8.39 (1H, d), 8.17 (2H, d), 7.56 (2H, d), 4.33 (1H, s), 4.31 (1H, m), 4.14 (2H, q), 3.29 (1H, dd), 3.15 (1H, dd), 1.43-1.70 (8H, m), 1.30 (1H , m), 1.15 (3H, t + 1H, m). Mass spectrum (ESI+) m/z: 373.3 [M+H]+.

References

[1] Patent: WO2004/7428, 2004, A1. Location in patent: Page 45
[2] Patent: WO2004/7428, 2004, A1. Location in patent: Page 47
[3] Patent: WO2004/7428, 2004, A1. Location in patent: Page 45-46

ETHYL 4-NITRO-L-PHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 4-NITRO-L-PHENYLALANINE Suppliers

China 43 India 2 United States 4 Global 49

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View Lastest Price from ETHYL 4-NITRO-L-PHENYLALANINE manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: 4-NO2-Phe-Oet 34276-53-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-03

Shaanxi Dideu Medichem Co. Ltd

Product: ETHYL 4-NITRO-L-PHENYLALANINE 34276-53-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-27

34276-53-4, ETHYL 4-NITRO-L-PHENYLALANINERelated Search:

4-NITRO-PHENYLALANINE METHYL ESTER ETHYL 4-NITRO-L-PHENYLALANINE 4-NITRO-L-PHENYLALANINE TERT-BUTYL ESTER HYDROCHLORIDE N-BOC-4-NITRO-L-PHENYLALANINE-T-BUTYL ESTER H-4-NITRO-PHE-OET HCL

ETHYL 4-NITRO-L-PHENYLALANINE

L-Phenylalanine, 4-nitro-, ethyl ester

p-Nitro-L-phenylalanine ethyl ester

(S)-Ethyl 2-amino-3-(4-nitrophenyl)propanoate

4-NO2-Phe-Oet

ETHYL 4-NITRO-L-PHENYLALANINE USP/EP/BP

Ethyl 4-nitro-L-phenylalanine,95%

4-NO2-Phe-Oet-OH

34276-53-4