ChemicalBook > CAS DataBase List > H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH

Product Name: H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH
CAS No.: 188859-65-6
Chemical Name: H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH
Synonyms: HSLGKLLGRPDKF;L144, R147-PLP(139-151);[LEU144, ARG147]-PLP (139-151);6:PN:WO0053019 SEQID:6 claimed sequence;HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;SER-HIS-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;(LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151);H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH;[Leu144, Arg147] - PLP (139 - 151), [L144, R147 - PLP(139 - 151)];L-Phenylalanine, L-histidyl-L-seryl-L-leucylglycyl-L-lysyl-L-leucyl-L-leucylglycyl-L-arginyl-L-prolyl-L-α-aspartyl-L-lysyl-
CBNumber: CB4153896
Molecular Formula: C67H110N20O17
Formula Weight: 1467.71
MOL File: Mol file

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H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: -15°C
pka: 3.49±0.10(Predicted)
Sequence: His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: LIP0001016
Product name: (LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151)
Purity: 95.00%
Packaging: 5MG
Price: $505.46
Updated: 2021/12/16

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H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH Chemical Properties,Usage,Production

Uses

[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1].

References

[1] Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9279-84. DOI:10.1073/pnas.94.17.9279

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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188859-65-6, H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OHRelated Search:

PLP (139-151)

[Leu144, Arg147] - PLP (139 - 151), [L144, R147 - PLP(139 - 151)]

SER-HIS-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE

(LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151)

[LEU144, ARG147]-PLP (139-151)

L144, R147-PLP(139-151)

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH

HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE

HSLGKLLGRPDKF

6:PN:WO0053019 SEQID:6 claimed sequence

L-Phenylalanine, L-histidyl-L-seryl-L-leucylglycyl-L-lysyl-L-leucyl-L-leucylglycyl-L-arginyl-L-prolyl-L-α-aspartyl-L-lysyl-

188859-65-6

C67H110N20O17

peptide