TRANS-4-CBZ-AMINOPHENOL

Product Name: TRANS-4-CBZ-AMINOPHENOL
CAS No.: 27489-63-0
Chemical Name: TRANS-4-CBZ-AMINOPHENOL
Synonyms: RANS-4-CBZ-AMINOPHENOL;TRANS-4-CBZ-AMINOPHENOL;1H-Pyrrole-2,5-dione,8-methyl-;TRANS-4-N-CBZ-AMINOCYCLOHEXANOL;trans-N-Cbz-4-aminocyclohexanol;trans-4-(Cbz-amino)cyclohexanol;Acetamide,N,N'-1,6-phenylenebis-;trans-4-(Cbz-aMino)cyclohexan-1-ol;Benzyl (trans-4-hydroxycyclohexyl);TRANS-4-HYDROXY-N-Z-CYCLOHEXYLAMINE
CBNumber: CB4154787
Molecular Formula: C14H19NO3
Formula Weight: 249.31
MOL File: 27489-63-0.mol

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TRANS-4-CBZ-AMINOPHENOL Property

Boiling point:: 427.6±44.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.15±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 2622AB
Product name: Benzyl(trans-4-hydroxycyclohexyl)carbamate
Packaging: 1g
Price: $70
Updated: 2021/12/16

Apolloscientific

Product number: OR912410
Product name: trans-4-(Cbz-amino)cyclohexan-1-ol
Purity: 97%
Packaging: 1g
Price: $138
Updated: 2021/12/16

Apolloscientific

Product number: OR912410
Product name: trans-4-(Cbz-amino)cyclohexan-1-ol
Purity: 97%
Packaging: 5g
Price: $348
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391947
Product name: BENZYL-(TRANS-4-HYDROXYCYCLOHEXYL)CARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $498.54
Updated: 2021/12/16

Apolloscientific

Product number: OR912410
Product name: trans-4-(Cbz-amino)cyclohexan-1-ol
Purity: 97%
Packaging: 25g
Price: $1044
Updated: 2021/12/16

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TRANS-4-CBZ-AMINOPHENOL Chemical Properties,Usage,Production

Synthesis

27489-62-9

501-53-1

27489-63-0

Using trans-p-aminocyclohexanol (1.15 g, 10 mmol) and benzyl chloroformate (2.14 g, 12 mmol) as raw materials, both were co-dissolved with triethylamine (1.23 g, 12 mmol) in acetonitrile and the reaction was stirred for 1 hr at 0-5 °C. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and water, the organic layer was separated and washed twice (10 mL each) with distilled water. The organic layer was dried over anhydrous sodium sulfate, 1 g of silica gel was added, and the solvent was evaporated under reduced pressure to give a dry solid. This solid was placed on top of a silica gel column and separated by column chromatography using chloroform and methanol as eluents. The eluates containing the target product (detected by TLC) were collected, combined and the solvents were evaporated under reduced pressure to give the white solid product (trans-4-hydroxycyclohexyl) benzyl carbamate in 90% yield. The melting point of the product was 161.6-163.8 °C (literature value 163-165 °C); the TLC Rf value was 0.49 (chloroform:methanol = 20:1); 1H NMR (CDCl3) δ 1.25 (m, 2H, CH2), 1.39 (m, 2H, CH2), 1.50 (d, J = 4.00 Hz, 1H, exchangeable, OH), 1.97 ( m, 4H, CH2), 3.51 (m, 1H, NCH), 3.60 (m, 1H, OCH), 4.60 (br, 1H, exchangeable, NH), 5.10 (s, 2H, CH2), 7.38 (m, 5H, ArH); HPLC purity >95%; ESI-MS m/z [M+H]+, calculated value 250.14, measured value 250.22.

References

[1] Chimia, 2005, vol. 59, # 3, p. 72 - 76
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2437 - 2451
[3] Journal of the American Chemical Society, 2003, vol. 125, # 49, p. 15191 - 15199
[4] Chemistry - A European Journal, 2012, vol. 18, # 4, p. 1127 - 1141
[5] Patent: WO2009/131687, 2009, A2. Location in patent: Page/Page column 188

TRANS-4-CBZ-AMINOPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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TRANS-4-CBZ-AMINOPHENOL Suppliers

China 49 India 1 United Kingdom 2 United States 9 Global 61

Goodee Pharma Co., Ltd.

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Amber MolTech LLC

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Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

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Shanghai Yolne Chemical Co., Ltd.

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Shanghai Raise Chemical Technology Co.,Ltd

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Bide Pharmatech Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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27489-63-0, TRANS-4-CBZ-AMINOPHENOLRelated Search:

Ethylene glycol 2-cyclohexylaminoethanesulfonic acid 3-AMINO-2-CYCLOHEXEN-1-ONE Diaminodicyclohexylmethane (1R*,2R*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-HYDROXY-CYCLOHEXANECARBOXYLIC ACID TRANS-4-CBZ-AMINOPHENOL N-CBZ-4-HYDROXYCYCLOHEXANE TRANS-4-CBZ-AMINOCYCLOHEXYL P-TOLUENESULPHONATE (1R*,2R*,5R*)-2-BENZYLOXYCARBONYLAMINO-5-(TOLUENE-4-SULFONYLOXY)-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER (1R*,2R*,5R*)-(7-OXO-6-OXA-BICYCLO[3.2.1]OCT-2-YL)-CARBAMIC ACID BENZYL ESTER BENZYL 4,5,6-TRIHYDROXYCYCLOHEXANE-1,3-DIYLDICARBAMATE

TRANS-4-CBZ-AMINOPHENOL

TRANS-4-N-CBZ-AMINOCYCLOHEXANOL

TRANS-4-HYDROXY-N-Z-CYCLOHEXYLAMINE

trans-1-Cbz-amino-4-hydroxycyclohexane

trans-N-Cbz-4-aminocyclohexanol

trans-4-<(benzyloxycarbonyl)aMino>cyclohexanol

trans-4-(Cbz-aMino)cyclohexan-1-ol

Benzyl (trans-4-hydroxycyclohexyl)carbaMate

trans-Benzyl -4-hydroxycyclohexylcarbaMate

CarbaMic acid,N-(trans-4-hydroxycyclohexyl)-, phenylMethyl ester

(1R,4R)-(4-Hydroxy-cyclohexyl)-carbaMic acid benzyl ester

Benzyl (trans-4-hydroxycyclohexyl)

benzyl (4-hydroxycyclohexyl)carbamate27489-63-0

RANS-4-CBZ-AMINOPHENOL

trans-4-(Cbz-amino)cyclohexanol

Carbamic acid, (trans-4-hydroxycyclohexyl)-, phenylmethyl ester

Acetamide,N,N'-1,6-phenylenebis-

1H-Pyrrole-2,5-dione,8-methyl-

Phenylmethyl N-(trans-4-hydroxycyclohexyl)carbamate

trans-4-(Benzyloxycarbonylamino)cyclohexan-1-ol

benzyl trans-N-(4-hydroxycyclohexyl)carbamate

benzyl Rel-((1r,4r)-4-hydroxycyclohexyl)carbamate

27489-63-0

pharmacetical