ethyl 4,4,4-trifluorobut-2-enoate Property

Density 

1.125 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.3601(lit.)

Flash point:

26°C

form 

liquid

Boiling point:

114-115°C(lit.)

Safety

RIDADR 

UN 3272 3 / PGIII

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

ethyl 4,4,4-trifluorobut-2-enoate Chemical Properties,Usage,Production

Uses

Ethyl 4,4,4-trifluorocrotonate was used in the synthesis of (2S,3S)-3-methyl- and (2S,3S)-3-trifluoromethylpyroglutamic acid. It undergoes diastereoselective Michael addition reaction with ethyl crotonate.

General Description

The Michael reaction between ethyl 4,4,4-trifluorocrotonate and a Ni(II) complex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone was studied.