1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
- Product Name
- 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
- CAS No.
- 865449-63-4
- Chemical Name
- 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
- Synonyms
- 4-Bromo-5-fluoro-2-hydroxyacetophenone;1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone;1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethan-1-one;Ethanone, 1-(4-bromo-5-fluoro-2-hydroxyphenyl)-
- CBNumber
- CB41555987
- Molecular Formula
- C8H6BrFO2
- Formula Weight
- 233.03
- MOL File
- 865449-63-4.mol
1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone Property
- Boiling point:
- 302.7±42.0 °C(Predicted)
- Density
- 1.667±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.23±0.23(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8379DK
- Product name
- 1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethanone
- Packaging
- 250mg
- Price
- $216
- Updated
- 2021/12/16
- Product number
- PC201330
- Product name
- 1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethanone
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- HCH0064757
- Product name
- 1-(4-BROMO-5-FLUORO-2-HYDROXYPHENYL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.33
- Updated
- 2021/12/16
- Product number
- A149891
- Product name
- 1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethanone
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A149891
- Product name
- 1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethanone
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone Chemical Properties,Usage,Production
Synthesis
286836-26-8
865449-63-4
The general procedure for the synthesis of 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone using 3-bromo-4-fluorophenyl acetate as starting material was as follows: 3-bromo-4-fluorophenyl acetate (5.5 g, 23 mmol) was dissolved in boron trifluoride acetic acid complex (47 mL, 340 mmol), and the reaction was heated for 14 hours at 155 °C. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and treated with ice water. After the ice bath was removed, the ice was allowed to melt naturally. Subsequently, the reaction mixture was diluted with cold water and filtered. The collected solid was washed with cold water and dried in air. The dried product was adsorbed on silica gel and purified by fast column chromatography with a gradient ratio of hexane/ethyl acetate (0%-30%) as eluent, resulting in the target product 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone (4.0 g, 73% yield). It is to be noted that no ionization signal was observed in mass spectrometry analysis for this product.
References
[1] Patent: WO2011/75630, 2011, A1. Location in patent: Page/Page column 107
[2] Patent: US2005/209274, 2005, A1. Location in patent: Page/Page column 42
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 19, p. 4851 - 4856
[4] Patent: EP3381896, 2018, A1. Location in patent: Paragraph 0455
1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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