2-(6-bromopyridin-2-yl)ethanol
- Product Name
- 2-(6-bromopyridin-2-yl)ethanol
- CAS No.
- 955370-07-7
- Chemical Name
- 2-(6-bromopyridin-2-yl)ethanol
- Synonyms
- 6-BroMo-2-pyridineethanol;2-Pyridineethanol, 6-bromo-;2-(6-bromopyridin-2-yl)ethanol;2-(6-Ethenylpyridin-2-yl)ethanol;2-(6-bromopyridin-2-yl)ethan-1-ol;2-Bromo-6-(2-hydroxyethyl)pyridine
- CBNumber
- CB41557219
- Molecular Formula
- C7H8BrNO
- Formula Weight
- 202.05
- MOL File
- 955370-07-7.mol
2-(6-bromopyridin-2-yl)ethanol Property
- Boiling point:
- 292.0±25.0 °C(Predicted)
- Density
- 1.564±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.37±0.10(Predicted)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B686800
- Product name
- 2-(6-Bromopyridin-2-yl)ethanol
- Packaging
- 2.5g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- OR471389
- Product name
- 2-Bromo-6-(2-hydroxyethyl)pyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 4H56-9-8T
- Product name
- 2-Bromo-6-(2-hydroxyethyl)pyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 057376
- Product name
- 2-(6-Bromopyridin-2-yl)ethanol
- Purity
- 95%
- Packaging
- 500mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- OR471389
- Product name
- 2-Bromo-6-(2-hydroxyethyl)pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $279
- Updated
- 2021/12/16
2-(6-bromopyridin-2-yl)ethanol Chemical Properties,Usage,Production
Uses
2-(6-bromopyridin-2-yl)ethanol is used in the preparation of 2,6-diaminopyridine compounds for treating diseases associated with amyloid or amyloid-like proteins, especially ocular diseases.
Synthesis
5315-25-3
68-12-2
955370-07-7
The general procedure for the synthesis of 2-(6-bromopyridin-2-yl)ethanol from 2-bromo-6-methylpyridine and N,N-dimethylformamide was as follows: first, a hexane solution of 1.6 M n-butyllithium (51 mL, 81.2 mmol) was slowly added to a solution of tetrabutane containing N,N'-diisopropylamine (13.5 mL, 97.4 mmol) and tetrahydrofuran ( 60 mL) in a stirred solution to prepare the LDA solution. The mixture was stirred at 0 °C for 15 min before being cooled to -78 °C and a solution of 2-bromo-6-methylpyridine (5 g, 29.1 mmol) in tetrahydrofuran (90 mL) was added. Stirring was continued at -78 °C for 25 min, followed by the addition of N,N-dimethylformamide (7.9 mL, 107 mmol). After 30 minutes of reaction, methanol (80 mL) and acetic acid (6.1 mL, 132 mmol) were added sequentially. Subsequently, sodium borohydride (1.1 g, 28 mmol) was added at -78 °C and the mixture was stirred overnight and naturally warmed to room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (150 mL) and washed sequentially with 10% citric acid solution (80 mL) and brine (80 mL). The organic phase was separated and the aqueous phase was extracted with ethyl acetate (2 x 150 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane/acetone (95/5) as eluent to afford 2-(6-bromopyridin-2-yl)ethanol as a light yellow oil (5 g, 85% yield).1H-NMR (400 MHz, CDCl3): δ=3.01 (t, 2H), 3.09 (t, 1H), 4.02 (q, 2H), 7.16 ( d, 1H), 7.34 (d, 1H), 7.43 (t, 1H).
References
[1] Patent: US2011/92537, 2011, A1. Location in patent: Page/Page column 25-26
[2] Patent: EP2311823, 2011, A1. Location in patent: Page/Page column 26; 28
[3] Patent: WO2011/45383, 2011, A2. Location in patent: Page/Page column 56
[4] Patent: WO2015/110263, 2015, A1. Location in patent: Page/Page column 198
2-(6-bromopyridin-2-yl)ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
2-(6-bromopyridin-2-yl)ethanol Suppliers
- Tel
- --
- Fax
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- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
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View Lastest Price from 2-(6-bromopyridin-2-yl)ethanol manufacturers
- Product
- 2-(6-bromopyridin-2-yl)ethanol 955370-07-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31
- Product
- 2-(6-BROMOPYRIDIN-2-YL)BENZALDEHYDE 955370-07-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31