4-BORONO-L-PHENYLALANINE

Product Name: 4-BORONO-L-PHENYLALANINE
CAS No.: 76410-58-7
Chemical Name: 4-BORONO-L-PHENYLALANINE
Synonyms: 4-boronophenylalanine;4-dihydroxyboryl-l-phenylalanine;4-L-BPA;EOS-61315;L-PHE[B(OH)2];H-S-PHE(4-B(OH)2)-OH;Lisinopril Impurity 26;4-BORONO-L-PHENYLALANIN;L-p-Boronophenylalanine;4-BORONO-L-PHENYLALANINE
CBNumber: CB4155764
Molecular Formula: C9H12BNO4
Formula Weight: 209.01
MOL File: 76410-58-7.mol

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4-BORONO-L-PHENYLALANINE Property

Melting point:: 285-293℃ (dec.)
Boiling point:: 449.3±55.0 °C(Predicted)
Density: 1.34±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Inert atmosphere,2-8°C
solubility: Aqueous Acid (Slightly)
pka: 2.20±0.10(Predicted)
form: Powder
color: White to off-white
BRN: 4458616
InChI: InChI=1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1
InChIKey: NFIVJOSXJDORSP-QMMMGPOBSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(B(O)O)C=C1)N
CAS DataBase Reference: 76410-58-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 1-10
HazardClass: IRRITANT
HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 17755
Product name: 4-Borono-L-phenylalanine
Purity: ≥95.0% (HPLC)
Packaging: 250mg
Price: $323
Updated: 2025/07/31

TCI Chemical

Product number: B6405
Product name: 4-Borono-L-phenylalanine (contains varying amounts of Anhydride)
Packaging: 250MG
Price: $167
Updated: 2025/07/31

TRC

Product number: B675600
Product name: 4-Borono-L-phenylalanine
Packaging: 500mg
Price: $425
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139059
Product name: 4-Borono-L-phenylalanine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J93161
Product name: 4-Borono-L-phenylalanine
Packaging: 100mg
Price: $80
Updated: 2021/12/16

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4-BORONO-L-PHENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

4-Borono-L-phenylalanine is an unnatural derivative of L-Phenylalanine (P319415). a nonpolar, essential amino acid that naturally occurs in the human body and is also used to treat patients with depression. 4-Borono-L-phenylalanine is also being used as a mediator in sequential boron neutron capture therapy, a new method of treating oral cancer.

Synthesis

119771-23-2

76410-58-7

The general procedure for the synthesis of (S)-2-amino-3-(4-boronic acid phenyl)propionic acid from (S)-3-(4-boronic acid phenyl)-2-((tert-butoxycarbonyl)amino)propionic acid was as follows: (S)-N-Boc-4-borophenylalanine (5.63 g, 98.5% purity, 17.9 mmol) was suspended in a solvent mixture of acetone (34 mL) and water (3.8 mL). Concentrated hydrochloric acid (37%, 3.8 mL) was added slowly under stirring to form an acidic reaction system. The reaction system was stirred at 55 °C for 1.5 h. HPLC showed that the reaction was complete. The reaction system was cooled to room temperature and the pH was adjusted to 1.5 with aqueous sodium hydroxide solution and stirred for 30 min, during which (S)-2-amino-3-(4-boronic acid phenyl)propionic acid started to precipitate. Subsequently, the pH of the reaction system was re-adjusted to 6.2 with aqueous sodium hydroxide and stirring was continued overnight at room temperature. Upon completion of the reaction, the solid product was collected by filtration to afford (S)-2-amino-3-(4-boronic acid phenyl)propionic acid.

References

[1] Patent: EP2865682, 2015, A1. Location in patent: Paragraph 0077; 0078
[2] Patent: US2018/155368, 2018, A1. Location in patent: Paragraph 0123-0128
[3] Bulletin of the Chemical Society of Japan, 2000, vol. 73, # 1, p. 231 - 235

4-BORONO-L-PHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BORONO-L-PHENYLALANINE Suppliers

Belgium 1 China 161 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 9 United States 21 Global 200

Shanghai Peiling Biological Technology Co., LTD

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Xiamen Yunfan Biotech Co., Ltd.

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Energy Chemical

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Capot Chemical Co., Ltd

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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

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View Lastest Price from 4-BORONO-L-PHENYLALANINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-BORONO-L-PHENYLALANINE 76410-58-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 4-BORONO-L-PHENYLALANINE 76410-58-7
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

76410-58-7, 4-BORONO-L-PHENYLALANINERelated Search:

3,4-Dimethoxy-L-phenylalanine H-D-3,4-DMP-OH FMOC-3,4-DIMETHOXY-L-PHENYLALANINE BOC-3,4-DIMETHOXY-L-PHENYLALANINE BOC-D-3,4-DIMETHOXYPHENYLALANINE FMOC-D-3,4-DIMETHOXYPHENYLALANINE L-4-Iodophenylalanine D-4-PHENYLALANINEBORONIC ACID,4-BORONO-D-PHENYLALANINE 97%,4-BORONO-D-PHENYLALANINE,4-BORONO-D-PHENYLALANINE B10 ENRICHED DL-4-PHENYLALANINEBORONIC ACID,4-BORONO-DL-PHENYLALANINE B10 ENRICHED,4-BORONO-DL-PHENYLALANINE 3-BORONO-D-PHENYLALANINE 2-BORONO-D-PHENYLALANINE 2-BORONO-L-PHENYLALANINE 3-BORONO-L-PHENYLALANINE (S)-BOC-4-BORONO-PHENYLALANINE FMOC-L-PHE(4-B(OH)2)-OH 4-BORONO-L-PHENYLALANINE

(S)-(4-BORONIC ACID)-PHENYLALANINE

4-BORONO-L-PHENYLALANINE

4-BORONO-L-PHENYLALANINE B10 ENRICHED

L-PHE[B(OH)2]

H-S-PHE(4-B(OH)2)-OH

L-4-PHENYLALANINEBORONIC ACID

4-boronophenylalanine

4-L-BPA

4-dihydroxyboryl-l-phenylalanine

4-Dihydroxyboryl-L-phenylalanine, L-BPA

4-Borono-L-phenylalanine,97%

4-Borono-L-phenylalanine, L-4-Phenylalanineboronic acid

L-4-(2-Amino-2-carboxyethyl)benzeneboronic acid

4-BORONO-L-PHENYLALANIN

EOS-61315

L-Phenylalanine,4-borono-

(S)-2-AMino-3-(4-boronophenyl)propanoic acid

(2S)-2-aMino-3-[4-(dihydroxyboranyl)phenyl]propanoic acid

4-Borono-L-phenylalanine,99%+

4-BORONO-L-PHENYLALANINE USP/EP/BP

4-Borono-L-phenylalanine, L-BPA

L-p-Boronophenylalanine

4-Borono-L-phenylalanine (contains varying amounts of Anhydride)

(s)-2-amino-3-(4-boronophenyl)propanoic acid|||L-p-Boronophenylalanine

Lisinopril Impurity 26

4-Borono-<sc>L</sc>-phenylalanine

4-Borono-L-phenylalanine - [B5003]

76410-58-7

Phenylalanine Derivatives

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Boronic Acids