3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester
Uses- Product Name
- 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester
- CAS No.
- 142166-01-6
- Chemical Name
- 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester
- Synonyms
- methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester;methyl methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl es...;2H-1,4-Benzoxazine-7-carboxylic acid, 3,4-dihydro-, methyl ester;3,4-Dihydro-7-(methoxycarbonyl)-2H-1,4-benzoxazine, 3,4-Dihydro-7-(methoxycarbonyl)-2H-benzo[b][1,4]oxazine
- CBNumber
- CB41558645
- Molecular Formula
- C10H11NO3
- Formula Weight
- 193.2
- MOL File
- 142166-01-6.mol
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Property
- Melting point:
- 86～88℃
- Boiling point:
- 337.2±41.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 2.00±0.20(Predicted)
- Appearance
- Off-white to brown Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D454888
- Product name
- 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylicacidmethylester
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR16468
- Product name
- Methyl3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate
- Packaging
- 250mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 4H23-1-Y3
- Product name
- Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 6938AA
- Product name
- Methyl3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate
- Packaging
- 5g
- Price
- $511
- Updated
- 2021/12/16
- Product number
- 6938AA
- Product name
- Methyl3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate
- Packaging
- 10g
- Price
- $817
- Updated
- 2021/12/16
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate is used as a research compound and in organic synthesis, etc.
Synthesis
142166-00-5
142166-01-6
Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate (1 g, 4.83 mmol) was used as starting material and mixed with boron trifluoride ethyl ether complex (1.273 mL, 10.14 mmol) in tetrahydrofuran (20 mL). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, sodium borohydride (0.383 g, 10.14 mmol) was slowly added to the reaction system and stirring was continued at 0 °C for 1 h. The reaction was then brought to room temperature overnight. Upon completion of the reaction, ethyl acetate (~1 mL) was added to dilute the reaction, which was subsequently quenched by the addition of 1N aqueous hydrochloric acid. Extraction was carried out with ethyl acetate at room temperature, and the organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to afford the target product, methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate (0.916 g, 4.74 mmol, 98% yield), as a light yellow solid.
References
[1] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0658
[2] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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