2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one
- Product Name
- 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one
- CAS No.
- 1197-66-6
- Chemical Name
- 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one
- Synonyms
- 2,2,6,6-tetramethyloxan-4-one;2,2,6,6-Tetramethyldihydropyran-4(3H)-one;2,2,6,6-tetraMethyl-tetrahydropyran-4-one;tetrahydro-2,2,6,6-tetraMethylpyran-4-one;2,2,6,6-Tetramethyltetrahydro-4H-pyran-4-one;2,2,6,6-tetramethyldihydro-2H-pyran-4(3H)-one;Tetrahydro-2,2,6,6-tetraMethyl-4H-pyran-4-one;4H-Pyran-4-one,tetrahydro-2,2,6,6-tetraMethyl-;2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one
- CBNumber
- CB41563502
- Molecular Formula
- C9H16O2
- Formula Weight
- 156.22
- MOL File
- 1197-66-6.mol
2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one Property
- Melting point:
- 12.8 °C
- Boiling point:
- 73-75 °C(Press: 17 Torr)
- Density
- 0.9485 g/cm3
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C9H16O2/c1-8(2)5-7(10)6-9(3,4)11-8/h5-6H2,1-4H3
- InChIKey
- NOGFHTGYPKWWRX-UHFFFAOYSA-N
- SMILES
- C1(C)(C)OC(C)(C)CC(=O)C1
Safety
- HS Code
- 2914500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T305620
- Product name
- 2,2,6,6-Tetramethyl-2h-3,5,6-trihydropyran-4-one
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- P000025324
- Product name
- 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 122730
- Product name
- Tetrahydro-2,2,6,6-tetramethylpyran-4-one
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- P000025324
- Product name
- 2,2,6,6-Tetramethyl-2H-3,5,6-trihydropyran-4-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- Y7211
- Product name
- Tetrahydro-2,2,6,6-tetramethylpyran-4-one
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one Chemical Properties,Usage,Production
Uses
2,2,6,6-Tetramethyl-2h-3,5,6-trihydropyran-4-one is a chemical reagent used in the synthesis of Nodulisporic Acid, a potent and systemic insecticide.
Synthesis
504-20-1
1197-66-6
General procedure for the synthesis of 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one using 2,6-dimethyl-2,5-heptadien-4-one as starting material: 5 g of 2,6-dimethyl-2,5-heptadien-4-one was dissolved in 36 mL of 1 M hydrochloric acid solution and the reaction was heated for 48 hours at 40 °C. Upon completion of the reaction, the reaction mixture was distilled (63-65 °C fraction was collected) to give 3.0 g of a light yellow oily product in 53% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 1.25 (m, 4H); 2.3 (m, 12H).
References
[1] Patent: WO2010/63773, 2010, A1. Location in patent: Page/Page column 23-24
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1425 - 1435
[3] Tetrahedron Letters, 1999, vol. 40, # 38, p. 6909 - 6912
[4] Patent: WO2015/23289, 2015, A1. Location in patent: Page/Page column 52
[5] Patent: US2015/51225, 2015, A1. Location in patent: Paragraph 0320; 0321
2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one manufacturers
- Product
- 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one 1197-66-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one 1197-66-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25