2,8-Dibromoquinoline
- Product Name
- 2,8-Dibromoquinoline
- CAS No.
- 871507-79-8
- Chemical Name
- 2,8-Dibromoquinoline
- Synonyms
- 2,8-Dibromoquinoline;Quinoline, 2,8-dibroMo-
- CBNumber
- CB41564332
- Molecular Formula
- C9H5Br2N
- Formula Weight
- 286.95
- MOL File
- 871507-79-8.mol
2,8-Dibromoquinoline Property
- Melting point:
- 118-119 °C
- Boiling point:
- 349.4±22.0 °C(Predicted)
- Density
- 1.923±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.16±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD53403
- Product name
- 2,8-Dibromoquinoline
- Packaging
- 25mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 119857
- Product name
- 2,8-Dibromoquinoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- Z5228
- Product name
- 2,8-Dibromoquinoline
- Packaging
- 250mg
- Price
- $264
- Updated
- 2021/12/16
- Product number
- FD53403
- Product name
- 2,8-Dibromoquinoline
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- 119857
- Product name
- 2,8-Dibromoquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $465
- Updated
- 2021/12/16
2,8-Dibromoquinoline Chemical Properties,Usage,Production
Synthesis
67805-67-8
871507-79-8
Step 2C: Preparation of 2,8-dibromoquinoline: 8-bromo-1H-2-quinolinone (5 g, 22 mmol) was mixed with phosphorus tribromide (13 g, 45 mmol), heated to 140 °C and reacted for 3 hours. After completion of the reaction, the mixture was slowly poured into a pre-prepared ice-water mixture (100 g ice with 100 mL water). After continuous stirring for 1 h, the precipitated solid was collected by filtration to afford the target product 2,8-dibromoquinoline (5.1 g, 80% yield). The product was confirmed by mass spectrometry analysis (APCI+ mode), detecting m/z 286, 288, and 290 (corresponding to [M+1]+ peaks for different combinations of bromine isotopes).
References
[1] Tetrahedron Letters, 2005, vol. 46, # 48, p. 8419 - 8422
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 868 - 877
[3] Patent: WO2008/124323, 2008, A1. Location in patent: Page/Page column 29
[4] Patent: WO2008/121687, 2008, A2. Location in patent: Page/Page column 28
[5] Organometallics, 2018, vol. 37, # 16, p. 2760 - 2768
2,8-Dibromoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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