ChemicalBook > CAS DataBase List > SL 327

SL 327

Product Name
SL 327
CAS No.
305350-87-2
Chemical Name
SL 327
Synonyms
SL 327;CS-1890;SL 327; SL-327;SL 327 USP/EP/BP;MEK Inhibitor VII;Mek-1/Mek-2 Inhibitor;MEK Inhibitor VII SL327 SL-327;SL327;SL-327;MEK-1/MEK-2 INHIBITOR;3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile;α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
CBNumber
CB4168773
Molecular Formula
C16H12F3N3S
Formula Weight
335.35
MOL File
305350-87-2.mol
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SL 327 Property

Melting point:
127-128.2 °C
Boiling point:
512.6±50.0 °C(Predicted)
Density 
1.40
storage temp. 
2-8°C
solubility 
DMSO: 32 mg/mL
form 
solid
pka
3.42±0.10(Predicted)
color 
white
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Safety

WGK Germany 
3
HS Code 
2930909899
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4069
Product name
SL327
Purity
≥98% (HPLC), Mixture of E & Z isomers, solid
Packaging
5mg
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
S4069
Product name
SL327
Purity
≥98% (HPLC), Mixture of E & Z isomers, solid
Packaging
25mg
Price
$251.2
Updated
2024/03/01
Cayman Chemical
Product number
15598
Product name
SL 327
Purity
≥95% (mixture of cis/trans isomers)
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
15598
Product name
SL 327
Purity
≥95% (mixture of cis/trans isomers)
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
15598
Product name
SL 327
Purity
≥95% (mixture of cis/trans isomers)
Packaging
10mg
Price
$139
Updated
2024/03/01
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SL 327 Chemical Properties,Usage,Production

Description

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.

Uses

SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.

Definition

ChEBI: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4 aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.

Biological Activity

Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

storage

+4°C (desiccate)

SL 327 Preparation Products And Raw materials

Raw materials

Preparation Products

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SL 327 Suppliers

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View Lastest Price from SL 327 manufacturers

Career Henan Chemical Co
Product
(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile 305350-87-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

305350-87-2, SL 327Related Search:

AS703026 Binimetinib Selumetinib 42-(Dimethylphosphinate)rapamycin BIX 02189 PD 0325901 Benzeneacetonitrile 2-(TRIFLUOROMETHYL)PHENYLACETONITRILE SL 327

  • ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
  • ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE
  • Mek-1/Mek-2 Inhibitor
  • SL327;SL-327;MEK-1/MEK-2 INHIBITOR
  • SL 327
  • Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
  • Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
  • a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
  • α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
  • α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
  • (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
  • MEK Inhibitor VII
  • (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
  • alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile SL 327
  • SL 327 alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
  • (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
  • SL 327; SL-327
  • CS-1890
  • Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
  • 3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
  • SL 327 USP/EP/BP
  • MEK Inhibitor VII SL327 SL-327
  • Mitogen-activated protein kinase kinase,SL327,MEK,inhibit,Inhibitor,MAPKK,MAP2K
  • Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
  • 305350-87-2
  • C16H12F3O3S
  • Kinase/Phosphatase Biology
  • Mitogen-Activated Protein Kinase Kinase (MAPKK)
  • Serine/Threonine Kinase Inhibitors
  • Cell Signaling and Neuroscience
  • BioChemical
  • Cell Biology
  • Inhibitors
  • Protein Kinase
  • Signalling
  • MAPK