ChemicalBook > CAS DataBase List > SL 327

SL 327

Product Name
SL 327
CAS No.
305350-87-2
Chemical Name
SL 327
Synonyms
SL 327;CS-1890;SL 327; SL-327;SL 327 USP/EP/BP;MEK Inhibitor VII;Mek-1/Mek-2 Inhibitor;MEK Inhibitor VII SL327 SL-327;SL327;SL-327;MEK-1/MEK-2 INHIBITOR;3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile;α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
CBNumber
CB4168773
Molecular Formula
C16H12F3N3S
Formula Weight
335.35
MOL File
305350-87-2.mol
More
Less

SL 327 Property

Melting point:
127-128.2 °C
Boiling point:
512.6±50.0 °C(Predicted)
Density 
1.40
storage temp. 
2-8°C
solubility 
DMSO: 32 mg/mL
form 
solid
pka
3.42±0.10(Predicted)
color 
white
More
Less

Safety

WGK Germany 
3
HS Code 
2930909899
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4069
Product name
SL327
Purity
≥98% (HPLC), Mixture of E & Z isomers, solid
Packaging
5mg
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
S4069
Product name
SL327
Purity
≥98% (HPLC), Mixture of E & Z isomers, solid
Packaging
25mg
Price
$251.2
Updated
2024/03/01
Cayman Chemical
Product number
15598
Product name
SL 327
Purity
≥95% (mixture of cis/trans isomers)
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
15598
Product name
SL 327
Purity
≥95% (mixture of cis/trans isomers)
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
15598
Product name
SL 327
Purity
≥95% (mixture of cis/trans isomers)
Packaging
10mg
Price
$139
Updated
2024/03/01
More
Less

SL 327 Chemical Properties,Usage,Production

Description

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.

Uses

SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.

Definition

ChEBI: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4 aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.

Biological Activity

Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

storage

+4°C (desiccate)

SL 327 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SL 327 Suppliers

China 104 Europe 1 Germany 2 India 1 Japan 1 Switzerland 1 United Kingdom 5 United States 20 Global 135
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
Tongling HengYou Biotechnology Co., Ltd.
Tel
021-50426030 13856289449
Fax
021-50426030
Email
2630597085@qq.com
Country
China
ProdList
1889
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5010
Advantage
55
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1847
Advantage
55
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28806
Advantage
58
Shanghai BetterBioChem Co., Ltd.
Tel
+86-18017644823
Fax
- QQ：1910610264
Email
sales@betterbiochem.com
Country
China
ProdList
325
Advantage
58
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9897
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
15502154572
Fax
-
Email
yuben012@sina.com
Country
China
ProdList
508
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3251
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1990
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
1990
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3960
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22883
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
Country
China
ProdList
5176
Advantage
58
Shandong chuangyingchemical Co., Ltd.
Tel
18853181302
Email
sale@chuangyingchem.com
Country
CHINA
ProdList
5906
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29811
Advantage
58
Shanghai Zeye Biotechnology Co., Ltd.
Tel
021-61998551 13122364865
Email
sale1@shzysw.net
Country
China
ProdList
9772
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
4297
Advantage
58
More
Less

View Lastest Price from SL 327 manufacturers

Career Henan Chemical Co
Product
(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile 305350-87-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

305350-87-2, SL 327Related Search:

AS703026 Binimetinib Selumetinib 42-(Dimethylphosphinate)rapamycin BIX 02189 PD 0325901 Benzeneacetonitrile 2-(TRIFLUOROMETHYL)PHENYLACETONITRILE SL 327

  • ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
  • ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE
  • Mek-1/Mek-2 Inhibitor
  • SL327;SL-327;MEK-1/MEK-2 INHIBITOR
  • SL 327
  • Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
  • Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
  • a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
  • α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
  • α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
  • (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
  • MEK Inhibitor VII
  • (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
  • alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile SL 327
  • SL 327 alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
  • (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
  • SL 327; SL-327
  • CS-1890
  • Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
  • 3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
  • SL 327 USP/EP/BP
  • MEK Inhibitor VII SL327 SL-327
  • Mitogen-activated protein kinase kinase,SL327,MEK,inhibit,Inhibitor,MAPKK,MAP2K
  • Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
  • 305350-87-2
  • C16H12F3O3S
  • Kinase/Phosphatase Biology
  • Mitogen-Activated Protein Kinase Kinase (MAPKK)
  • Serine/Threonine Kinase Inhibitors
  • Cell Signaling and Neuroscience
  • BioChemical
  • Cell Biology
  • Inhibitors
  • Protein Kinase
  • Signalling
  • MAPK