MASTOPARAN X
- Product Name
- MASTOPARAN X
- CAS No.
- 72093-22-2
- Chemical Name
- MASTOPARAN X
- Synonyms
- MP-X;MASTOPARAN X;INWKGIAAMAKKLL-NH2;ILE-ASN-TRP-LYS-GLY-ILE-ALA-ALA-MET-ALA-LYS-LYS-LEU-LEU-NH2;H-ILE-ASN-TRP-LYS-GLY-ILE-ALA-ALA-MET-ALA-LYS-LYS-LEU-LEU-NH2;L-Leucinamide, L-isoleucyl-L-asparaginyl-L-tryptophyl-L-lysylglycyl-L-isoleucyl-L-alanyl-L-alanyl-L-methionyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-
- CBNumber
- CB4170149
- Molecular Formula
- C73H126N20O15S
- Formula Weight
- 1555.97
- MOL File
- 72093-22-2.mol
MASTOPARAN X Property
- Boiling point:
- 1797.4±65.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- DMF: 25 mg/ml
DMSO: 25 mg/ml
Ethanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml - form
- Lyophilized solid.
- pka
- 13.24±0.46(Predicted)
- color
- White to off-white
Safety
- Safety Statements
- 22-24/25
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 255756
- Product name
- Mastoparan X
- Packaging
- 1mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- M2417X-01
- Product name
- Mastoparan X
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- PEP0002443
- Product name
- MASTOPARAN X
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $597.89
- Updated
- 2021/12/16
- Product number
- PEP0002443
- Product name
- MASTOPARAN X
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $735.63
- Updated
- 2021/12/16
MASTOPARAN X Chemical Properties,Usage,Production
Uses
Has effects similar to mastoparan; binds with high affinity to calmodulin and inhibits sarcoplasmic reticulum calcium-ATPase
Definition
ChEBI: Mastoparan-V is a member of the class of mastopyrans that is a 14-amino acid polypeptide comprising isoleucyl, asparaginyl, tryptophyl, lysyl, glycyl, isoleucyl, alanyl, alanyl, methionyl, alanyl, lysyl, lysyl, leucyl, and leucinamide residues coupled in sequence. It is the major active component of the venom of the hornet Vespa velutina and causes degranulation of mast cells. It exhibits antimicrobial activity against both Gram-positive and -negative bacteria as well as haemolytic activity on chicken, human and sheep erythrocytes. It has a role as an antibacterial agent. It is a member of mastoparans and a peptidyl amide.
References
[1] CHUN-HSIEN LIN . Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan[J]. Peptides, 2011, 32 10: Pages 2027-2036. DOI: 10.1016/j.peptides.2011.08.015
[2] DEAN A. MALENCIK Sonia R A. High affinity binding of the mastoparans by calmodulin[J]. Biochemical and biophysical research communications, 1983, 114 1: Pages 50-56. DOI: 10.1016/0006-291x(83)91592-9
[3] T HIGASHIJIMA E M R J Burnier. Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.[J]. The Journal of Biological Chemistry, 1990, 265 24: 14176-14186.
[4] ANNIELLE MENDES BRITO DA SILVA. Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action.[J]. Molecular Neurobiology, 2018: 5490-5504. DOI: 10.1007/s12035-017-0782-1
[5] XUEQIN ZHAO. The Antimicrobial Peptide Mastoparan X Protects Against Enterohemorrhagic Escherichia coli O157:H7 Infection, Inhibits Inflammation, and Enhances the Intestinal Epithelial Barrier.[J]. Frontiers in Microbiology, 2021: 644887. DOI: 10.3389/fmicb.2021.644887
MASTOPARAN X Preparation Products And Raw materials
Raw materials
Preparation Products
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