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L-2-AMINO-4-SULFOBUTYRIC ACID

Product Name
L-2-AMINO-4-SULFOBUTYRIC ACID
CAS No.
14857-77-3
Chemical Name
L-2-AMINO-4-SULFOBUTYRIC ACID
Synonyms
L-HOMOCYSTEIC ACID;L-Homocysteic acid;L-2-AMINO-4-SULFOBUTYRIC ACID;(S)-2-Amino-4-sulfobutanoic acid;Butanoic acid, 2-amino-4-sulfo-, (2S)-
CBNumber
CB4173807
Molecular Formula
C4H9NO5S
Formula Weight
183.18
MOL File
14857-77-3.mol
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L-2-AMINO-4-SULFOBUTYRIC ACID Property

Density 
1.638±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
powder
pka
1.40±0.50(Predicted)
color 
white to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H9633
Product name
L-Homocysteic acid
Packaging
25mg
Price
$66.8
Updated
2025/07/31
Sigma-Aldrich
Product number
H9633
Product name
L-Homocysteic acid
Packaging
1g
Price
$1230
Updated
2025/07/31
Sigma-Aldrich
Product number
H9633
Product name
L-Homocysteic acid
Packaging
250mg
Price
$371
Updated
2025/07/31
Sigma-Aldrich
Product number
H9633
Product name
L-Homocysteic acid
Packaging
100mg
Price
$182
Updated
2023/06/20
American Custom Chemicals Corporation
Product number
AAA0003869
Product name
L-HOMOCYSTEIC ACID
Purity
95.00%
Packaging
25MG
Price
$586.12
Updated
2021/12/16
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L-2-AMINO-4-SULFOBUTYRIC ACID Chemical Properties,Usage,Production

Uses

L-Homocysteic acid has been used to study hydrogen peroxide-mediated changes in physiological and pathological conditions in the nervous system.

Definition

ChEBI: A homocysteic acid with L-configuration.

Biochem/physiol Actions

L-Homocysteic acid (L-HCA) is an endogenous neurotransmitter ligand of NMDA (N-methyl-D-aspartate) receptors. It is an analog of glutamate and competitively suppresses glutamate-cystine (xc-) antiporter function in neurons, causing decrease in cysteine uptake.

in vivo

L-Homocysteic acid (intraperitoneal injection, 4-11 mmol/kg) elicits seizures in rats during early postnatal development[4].
L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats[5].

Animal Model:Male albino rats of the Wistar strain[4]
Dosage:4, 5.5, 8, 11 mM/kg
Administration:Intraperitoneal injection, daily for 14 days
Result:Induced flexion seizures at 4 mmol/kg.
Led to intense tail flicking, pivoting, and locomotion.
Decreased ECoG (electrocorticograms) activity for 5-9 min.

IC 50

NMDA Receptor: 14 μM (EC50)

L-2-AMINO-4-SULFOBUTYRIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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L-2-AMINO-4-SULFOBUTYRIC ACID Suppliers

China 14 Switzerland 2 United Kingdom 2 United States 6 Global 24
Shanghai Macklin Biochemical Co.,Ltd.
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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Merck KGaA
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Guangzhou WeiBo Chemical Co., Ltd.
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14857-77-3, L-2-AMINO-4-SULFOBUTYRIC ACIDRelated Search:

2-[(1-Oxooctadecyl)amino]-4-sulfobutyric acid D-2-AMINO-4-SULFOBUTYRIC ACID L-2-AMINO-4-SULFOBUTYRIC ACID DL-2-AMINO-4-SULFOBUTYRIC ACID L-HOMOCYSTEINESULFINIC ACID FMOC-4-(NEOPENTYLOXYSULFONYL)-ABU-OH

  • L-HOMOCYSTEIC ACID
  • L-2-AMINO-4-SULFOBUTYRIC ACID
  • (S)-2-Amino-4-sulfobutanoic acid
  • Butanoic acid, 2-amino-4-sulfo-, (2S)-
  • <sc>L</sc>-Homocysteic acid
  • 14857-77-3
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Ligand-Gated Ion Channels