(+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- Product Name
- (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- CAS No.
- 40615-02-9
- Chemical Name
- (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
- Synonyms
- 1,2,3,4-Tetrahydro-3-quinolinamine;1,2,3,4-Tetrahydroquinolin-3-aMine;3-QuinolinaMine, 1,2,3,4-tetrahydro-;(+/-)-3-Amino-1,2,3,4-tetrahydroquinoline;(+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE;(-3-Amino-1,2,3,4-tetrahydroquinoline2HCl;()-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 2HC;3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DIHYDROCHLORIDE
- CBNumber
- CB4173933
- Molecular Formula
- C9H12N2
- Formula Weight
- 148.21
- MOL File
- 40615-02-9.mol
(+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Property
- Boiling point:
- 292.1±29.0 °C(Predicted)
- Density
- 1.059±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.10±0.20(Predicted)
- Appearance
- Brown to black Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T796423
- Product name
- 1,2,3,4-Tetrahydroquinolin-3-amine
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P000613229
- Product name
- 1,2,3,4-Tetrahydroquinolin-3-amine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- P000613229
- Product name
- 1,2,3,4-Tetrahydroquinolin-3-amine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $23
- Updated
- 2021/12/16
- Product number
- P000613229
- Product name
- 1,2,3,4-Tetrahydroquinolin-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- P000613229
- Product name
- 1,2,3,4-Tetrahydroquinolin-3-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
(+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties,Usage,Production
Uses
1,2,3,4-Tetrahydroquinolin-3-amine is used in the preparation of state-dependant NaV1.7 inhibitors for the treatment of neuropathic pain.
Synthesis
580-17-6
40615-02-9
GENERAL METHOD: In a 1.5 mL reaction vial, tris(pentafluorophenyl)borane [B(C6F5)3] (0.025 mmol, 5.0 mol%) was dissolved in chloroform (0.60 mL), followed by the addition of diethylsilane (1.75 mmol, 3.5 equiv). After a short shaking, quinoline derivative (1a-p, 0.50 mmol, 1.0 eq.) was added to the above catalyst solution under argon protection. The reaction mixture was stirred at 25-65 °C for 6-24 h (for 1a-h) or at 25-100 °C for 2-24 h (for 1i-p) and subsequently cooled to room temperature. The reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was treated with an ether solution (7 mL) of 0.25 N HCl and stirred at room temperature for 1 h to give a solid residue, which was subsequently washed with ether. The solid residue was dissolved or suspended in methanol (1.0 mL) and neutralized with sodium carbonate monohydrate (Na2CO3-H2O, 0.5 g) at 0 °C. After stirring for 2 h, methanol was removed under reduced pressure and the neutralized reaction residue was dissolved in dichloromethane (CH2Cl2) and washed sequentially with brine (5 mL) and water (5 mL). The crude product was isolated from the organic phase of the dichloromethane solution and finally purified by silica gel column chromatography using ethyl acetate/hexane (1:9 for 2a-h; 3:7 for 2i-p) as eluent to give the target product 2a-p.
References
[1] Synlett, 2017, vol. 28, # 18, p. 2396 - 2400
[2] Journal of Medicinal Chemistry, 1982, vol. 25, # 1, p. 68 - 70
[3] Patent: US5719141, 1998, A
(+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
(+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE Suppliers
- Tel
- 0535-6385396
- Fax
- +86 (535) 638-9971
- info@carbottpharm.com
- Country
- China
- ProdList
- 957
- Advantage
- 56
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 13918479294
- Fax
- -
- xiebenfa@163.com
- Country
- China
- ProdList
- 4092
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 18616526224
- lianshuo@vip.126.com
- Country
- China
- ProdList
- 9607
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29798
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
View Lastest Price from (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE manufacturers
- Product
- (+/-)-3-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 40615-02-9
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12