3-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID
- Product Name
- 3-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID
- CAS No.
- 7311-93-5
- Chemical Name
- 3-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID
- Synonyms
- ST5432905;EU-0001412;Oprea1_803406;AG-205/06468016;BUTTPARK 148\07-59;3-piperidinosulfonylbenzoic acid;3-(1-piperidylsulfonyl)benzoic acid;3-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID;3-(Piperidin-1-ylsulfonyl)benzoic acid;3-(Piperidin-1-ylsulphonyl)benzoic acid
- CBNumber
- CB4174288
- Molecular Formula
- C12H15NO4S
- Formula Weight
- 269.32
- MOL File
- 7311-93-5.mol
3-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID Property
- Melting point:
- 179-181
- storage temp.
- Sealed in dry,Room Temperature
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B448925
- Product name
- 3-(Piperidin-1-ylsulfonyl)benzoicAcid
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 8H69-1-80
- Product name
- 3-(Piperidin-1-ylsulfonyl)benzoic acid
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- V7523
- Product name
- 3-(Piperidine-1-sulfonyl)benzoicacid
- Packaging
- 10g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- 047738
- Product name
- 3-(Piperidinosulfonyl)benzenecarboxylic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- CHM0022507
- Product name
- 3-(PIPERIDINOSULFONYL)BENZENECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $670.64
- Updated
- 2021/12/16
3-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID Chemical Properties,Usage,Production
Synthesis
110-89-4
4025-64-3
7311-93-5
To a stirred solution of 3-chlorosulfonylbenzoic acid (1.10 g, 5.00 mmol) in dichloromethane (DCM, 10 mL) was slowly added hexahydropyridine (piperidine, 1.49 g, 17.5 mmol) at 0 °C. The reaction mixture was continued to be stirred at 0 °C for 30 min. Upon completion of the reaction, the volatile solvent was removed by rotary evaporator under reduced pressure. The residue was treated with 1N aqueous solution of potassium bisulfate (KHSO4) to neutralize the excess piperidine. Subsequently, the aqueous phase was extracted with ethyl acetate (3 x 10 mL). The organic phases were combined and dried with anhydrous magnesium sulfate. After filtration to remove the desiccant, the filtrate was concentrated by rotary evaporator under reduced pressure to afford the white solid product 3-(piperidin-1-ylsulfonyl)benzoic acid (1.22 g, 90.4% yield). The structure of the product was confirmed by 1H NMR (d6-DMSO): δ 13.54 (1H, br s, COOH), 8.24 (1H, dt, J = 8.0, 1.4 Hz, Ar-H), 8.18 (1H, t, J = 1.8 Hz, Ar-H), 7.97 (1H, dt, J = 8.0, 1.6 Hz, Ar-H), 7.79 (1H, t, J = 7.7 Hz, Ar-H), 2.93-2.88 (4H, m, N-CH2), 1.58-1.50 (4H, m, CH2), 1.40-1.32 (2H, m, CH2).
References
[1] Patent: US2009/192195, 2009, A1. Location in patent: Page/Page column 13-14
[2] Patent: WO2016/16370, 2016, A1. Location in patent: Page/Page column 38; 39
[3] Patent: WO2009/93029, 2009, A1. Location in patent: Page/Page column 39
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6146 - 6155
[5] ChemMedChem, 2018, vol. 13, # 12, p. 1165 - 1171
3-(PIPERIDINE-1-SULFONYL)-BENZOIC ACID Preparation Products And Raw materials
Raw materials
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