BRACO 19

Product Name: BRACO 19
CAS No.: 351351-75-2
Chemical Name: BRACO 19
Synonyms: BRACO 19;BRACO 19 1-Pyrrolidinepropaneamide;1-Pyrrolidinepropanamide, N,N'-[9-[[4-(dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-;N,N'-(9-((4-(Dimethylamino)phenyl)amino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide);N,N'-(9-((4-(Dimethylamino)phenyl)amino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide)
CBNumber: CB41855348
Molecular Formula: C35H43N7O2
Formula Weight: 593.76
MOL File: 351351-75-2.mol

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BRACO 19 Property

Melting point:: >320 °C
Boiling point:: 854.9±65.0 °C(Predicted)
Density: 1.274±0.06 g/cm3(Predicted)
pka: 12.93±0.43(Predicted)
form: Solid
color: Brown to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC7809
Product name: BRACO19trihydrochloride
Purity: >98%
Packaging: 100mg
Price: $625
Updated: 2021/12/16

DC Chemicals

Product number: DC7809
Product name: BRACO19trihydrochloride
Purity: >98%
Packaging: 250mg
Price: $1250
Updated: 2021/12/16

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BRACO 19 Chemical Properties,Usage,Production

Uses

Braco-19 is a potent?telomerase/telomere?inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus?replication inhibitor[1][2].

Definition

ChEBI: N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide) is a member of acridines and a N-alkylpyrrolidine.

in vivo

BRACO-19 (oral administration or intraperitoneal injection; 2 or 5 mg/kg; 3 weeks) oral dosing regimen are always inactive and the animals have to be sacrificed due to high tumor burden before overall termination of the study, Chronic, i.p. BRACO-19 administration, qdx5 is efficient in inhibiting tumor growth in earlystage xenografts but not advanced-stage xenografts^[1]. BRACO-19 (intraperitoneal injection; 2 mg/kg; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments) inhibits tumor growth significantly and under these conditions, marked single-agent antitumor activity is observed, with some animals in the group showing complete regressions (5 of 12 tumors)^[1].

Animal Model:	Established UXF1138LX Xenografts in nude mice^[1]
Dosage:	2 mg/kg
Administration:	Intraperitoneal injection; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments
Result:	Showed partial tumor regressions with an optimal T/C on day 28 of 4.1%, equal to 95.9% inhibition of tumor growth compared with control.

References

[1] Angelika M Burger, et al. The G-quadruplex-interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent With Telomere Targeting and Interference With Telomerase Function. Cancer Res. 2005 Feb 15;65(4):1489-96. DOI:10.1158/0008-5472.CAN-04-2910
[2] Prativa Majee, et al. Genome-wide Analysis Reveals a Regulatory Role for G-quadruplexes During Adenovirus Multiplication. Virus Res. .?2020 Jul DOI:10.1016/j.virusres.2020.197960

BRACO 19 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRACO 19 Suppliers

China 12 Germany 1 United States 4 Global 17

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351351-75-2, BRACO 19Related Search:

BRACO 19

BRACO 19 1-Pyrrolidinepropaneamide

1-Pyrrolidinepropanamide, N,N'-[9-[[4-(dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-

N,N'-(9-((4-(Dimethylamino)phenyl)amino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide)

351351-75-2

C35H43N7O2