4-chloroquinoline-7-carboxylic acid
- Product Name
- 4-chloroquinoline-7-carboxylic acid
- CAS No.
- 49713-58-8
- Chemical Name
- 4-chloroquinoline-7-carboxylic acid
- Synonyms
- 4-chloro-7-quinolinecarboxylic acid;4-chloroquinoline-7-carboxylic acid;7-Quinolinecarboxylic acid, 4-chloro-;4-chloroquinoline-7-carboxylic acid - [C86828];2,2'-Biquinoline-4,4'-diyl bis(phosphine) iridium(I) complex;3-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)benzonitrile
- CBNumber
- CB41856138
- Molecular Formula
- C10H6ClNO2
- Formula Weight
- 207.61
- MOL File
- 49713-58-8.mol
4-chloroquinoline-7-carboxylic acid Property
- Boiling point:
- 364.2±27.0 °C(Predicted)
- Density
- 1.469±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.70±0.27(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B419378
- Product name
- 4-Chloroquinoline-7-carboxylicAcid
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 118922
- Product name
- 4-Chloroquinoline-7-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $287
- Updated
- 2021/12/16
- Product number
- 118922
- Product name
- 4-Chloroquinoline-7-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $717
- Updated
- 2021/12/16
- Product number
- Z4797
- Product name
- 4-Chloroquinoline-7-carboxylicacid
- Packaging
- 1g
- Price
- $1017
- Updated
- 2021/12/16
- Product number
- HCH0037112
- Product name
- 4-CHLOROQUINOLINE-7-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1431.05
- Updated
- 2021/12/16
4-chloroquinoline-7-carboxylic acid Chemical Properties,Usage,Production
Synthesis
346-55-4
49713-58-8
General procedure for the synthesis of 4-chloroquinoline-7-carboxylic acid from 4-chloro-7-trifluoromethylquinoline: 10.0 g (43.2 mmol) of 4-chloro-7-trifluoromethylquinoline was dissolved in 200 mL of concentrated hydrochloric acid. The reaction was heated in a microwave reactor with radiation at 550 W power for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and the pH was adjusted to 3-4 with sodium hydroxide solution.The precipitated product was collected by diafiltration, washed several times with deionized water and subsequently dried. Finally 8.9 g of 4-chloroquinoline-7-carboxylic acid was obtained in 99% yield of the theoretical value. Thin layer chromatography (TLC) analysis showed an Rf value of 0.45 (silica gel plate, unfolding agent was toluene/ethanol = 4:1). The molecular formula of the product was C10H6ClNO2 (molecular weight 207.62), and the mass spectrometry analysis showed that the molecular ion peak (M+H)+ was 208/210 (chlorine isotope peak).
References
[1] Patent: WO2004/58743, 2004, A1. Location in patent: Page/Page column 116-117
[2] Patent: WO2004/80970, 2004, A1. Location in patent: Page 34; 35
[3] Patent: WO2016/118565, 2016, A1. Location in patent: Paragraph 00320
[4] Patent: US2004/102450, 2004, A1. Location in patent: Page/Page column 72
[5] Patent: US5773449, 1998, A
4-chloroquinoline-7-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-chloroquinoline-7-carboxylic acid Suppliers
- Tel
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- Fax
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- sales@ajchem.in
- Country
- India
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View Lastest Price from 4-chloroquinoline-7-carboxylic acid manufacturers
- Product
- 4-chloroquinoline-7-carboxylic acid 49713-58-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08