ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
- Product Name
- ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
- CAS No.
- 577711-94-5
- Chemical Name
- ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
- Synonyms
- methyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate;ethyl 6-broMo-1H-pyrrolo[2;ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate;6-Bromo-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid ethyl ester;1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-broMo-, ethyl ester
- CBNumber
- CB41856198
- Molecular Formula
- C10H9BrN2O2
- Formula Weight
- 269.09
- MOL File
- 577711-94-5.mol
ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Property
- Density
- 1.624±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.96±0.40(Predicted)
- Appearance
- white solid
N-Bromosuccinimide Price
- Product number
- E900810
- Product name
- Ethyl6-bromo-1h-pyrrolo[2,3-b]pyridine-2-carboxylate
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- W7109
- Product name
- Ethyl6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
- Packaging
- 1g
- Price
- $1400
- Updated
- 2021/12/16
- Product number
- 070398
- Product name
- Ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
- Purity
- 96%
- Packaging
- 500mg
- Price
- $719
- Updated
- 2021/12/16
- Product number
- 070398
- Product name
- Ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
- Purity
- 96%
- Packaging
- 1g
- Price
- $1000
- Updated
- 2021/12/16
- Product number
- 070398
- Product name
- Ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
- Purity
- 96%
- Packaging
- 5g
- Price
- $3327
- Updated
- 2021/12/16
ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Chemical Properties,Usage,Production
Synthesis
577711-92-3
577711-94-5
General procedure for the synthesis of ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate from ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate: 18.4 g (0.05 mol) of ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 1-tert-butyl ester 2-ethyl ester was dissolved in 165 mL of dichloromethane and cooled to 0°C. 38.0 mL of trifluoroacetic acid was added slowly over 5 minutes. The cooling bath was removed and the reaction mixture was stirred at room temperature for 2 hours. Subsequently, the reaction mixture was poured into 500 mL of saturated aqueous sodium bicarbonate solution. The aqueous phase was extracted three times with 150 mL of dichloromethane and the organic phase was combined. The organic phase was washed with 200 mL of brine, dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated and the residue was dried under high vacuum to give 12.0 g (95.5%) of the target product, ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate, as a colorless solid.ISP-MS: m/e = 269.2 ([M+H]+).
References
[1] Patent: WO2005/849, 2005, A1. Location in patent: Page/Page column 62
[2] Patent: US2003/207888, 2003, A1
ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate Suppliers
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- Country
- India
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View Lastest Price from ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate manufacturers
- Product
- ethyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 577711-94-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12