Cyclobutanecarboxylic acid, 1-(aminomethyl)-, ethyl ester
Application- Product Name
- Cyclobutanecarboxylic acid, 1-(aminomethyl)-, ethyl ester
- CAS No.
- 911060-83-8
- Chemical Name
- Cyclobutanecarboxylic acid, 1-(aminomethyl)-, ethyl ester
- Synonyms
- ethyl 1-(aminomethyl)cyclobutanecarboxylate;ethyl 1-(aminomethyl)cyclobutane-1-carboxylate;1-Aminomethyl-cyclobutanecarboxylic acid ethyl ester;Cyclobutanecarboxylic acid, 1-(aminomethyl)-, ethyl ester
- CBNumber
- CB41859568
- Molecular Formula
- C8H15NO2
- Formula Weight
- 157.21
- MOL File
- 911060-83-8.mol
Cyclobutanecarboxylic acid, 1-(aminomethyl)-, ethyl ester Property
- Boiling point:
- 211.1±13.0 °C(Predicted)
- Density
- 1.060±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.27±0.29(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E939673
- Product name
- Ethyl1-(aminomethyl)cyclobutanecarboxylate
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CHM0125125
- Product name
- 1-AMINOMETHYL-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
- Purity
- 96.00%
- Packaging
- 5MG
- Price
- $503.1
- Updated
- 2021/12/16
- Product number
- X5529
- Product name
- Ethyl1-(aminomethyl)cyclobutanecarboxylate
- Packaging
- 250mg
- Price
- $264
- Updated
- 2021/12/16
- Product number
- X5529
- Product name
- Ethyl1-(aminomethyl)cyclobutanecarboxylate
- Packaging
- 1g
- Price
- $584
- Updated
- 2021/12/16
- Product number
- X5529
- Product name
- Ethyl1-(aminomethyl)cyclobutanecarboxylate
- Packaging
- 5g
- Price
- $1651
- Updated
- 2021/12/16
Cyclobutanecarboxylic acid, 1-(aminomethyl)-, ethyl ester Chemical Properties,Usage,Production
Application
Ethyl 1-(aminomethyl)cyclobutane carboxylate can be used as an organic intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes.
Synthesis
28246-87-9
911060-83-8
General procedure for the synthesis of ethyl 1-(aminomethyl)cyclobutanecarboxylate from ethyl 1-cyanocyclobutanecarboxylate: ethyl 1-cyanocyclobutanecarboxylate (2 g, 13 mmol) was dissolved in 1% ammonia in ethanol solution (20 mL), and 5% rhodium/alumina catalyst (0.8 g) was added, and the hydrogenation reaction was carried out at room temperature for 3 days. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated and dried to afford the target product ethyl 1-(aminomethyl)cyclobutanecarboxylate (1.5 g, 75%) as a light yellow liquid. The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ1.29 (t, J=7.1 Hz, 3H), 1.93-1.96 (m, 2H), 2.33-2.49 (m, 4H), 3.07 (s, 2H), 4.18 (q, J=7.2 Hz, 2H).
References
[1] Patent: WO2009/67547, 2009, A1. Location in patent: Page/Page column 281; 282
[2] Patent: WO2006/100208, 2006, A1. Location in patent: Page/Page column 50
Cyclobutanecarboxylic acid, 1-(aminomethyl)-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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