1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine

Product Name: 1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine
CAS No.: 1190380-49-4
Chemical Name: 1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine
Synonyms: 1-(oxan-4-yl)pyrazol-4-amine;1-(oxan-4-yl)-1H-pyrazol-4-amine;4-Amino-1-(4-tetrahydropyranyl)pyrazole;1-(Tetrahydropyran-4-yl)pyrazol-4-amine;1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine;1H-Pyrazol-4-amine, 1-(tetrahydro-2H-pyran-4-yl)-;4-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole, 4-(4-Amino-1H-pyrazol-1-yl)tetrahydro-2H-pyran
CBNumber: CB41873805
Molecular Formula: C8H13N3O
Formula Weight: 167.21
MOL File: 1190380-49-4.mol

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1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine Property

Boiling point:: 355.0±32.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.12±0.19(Predicted)
form: solid
color: Brown

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T294095
Product name: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine
Packaging: 500mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0054472
Product name: 1-(Tetrahydro-2H-pyran-4-yl)-1h-pyrazol-4-amine
Packaging: 5g
Price: $867
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H30-1-36
Product name: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine
Packaging: 5G
Price: $608
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 62000
Product name: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine
Packaging: 5G
Price: $2600
Updated: 2021/12/16

Apolloscientific

Product number: OR110577
Product name: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine
Packaging: 250mg
Price: $34
Updated: 2021/12/16

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1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine Chemical Properties,Usage,Production

Uses

1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine is used in the synthesis of Tyk2 inhibitors as well as in the preparation of pyrimidines as GCN2 inhibitors.

Synthesis

1190380-50-7

1190380-49-4

4-Nitro-1-(tetrahydropyran-4-yl)-1H-pyrazole (1.59 g, 8.07 mmol) was used as the starting material and mixed with 10% palladium/carbon catalyst in ethanol (30 mL). The reaction mixture was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through diatomaceous earth and the filtrate was subsequently concentrated to afford the target compound 1-tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine as a purple solid (1.33 g, 98% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 1.76-1.94 (m, 4H), 3.29-3.48 (m, 2H), 3.80 (br.s, 2H), 3.84-4.00 (m, 2H), 4.16 (tt, J = 10.42, 5.38 Hz, 1H), 6.90 (s, 1H), and 7.06 (s, 1H); mass spectrum (ES + APCI+): m/z 168 [M+H]+.

References

[1] Patent: WO2009/122180, 2009, A1. Location in patent: Page/Page column 111-112
[2] Patent: WO2009/155565, 2009, A1. Location in patent: Page/Page column 153
[3] Patent: WO2009/155551, 2009, A1. Location in patent: Page/Page column 116
[4] Patent: US2010/317643, 2010, A1. Location in patent: Page/Page column 98
[5] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0285; 0287

1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine Suppliers

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1190380-49-4, 1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amineRelated Search:

1-Tetrahydro-2H-pyran-4-yl-1H-pyrazol-4-amine

4-Amino-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole, 4-(4-Amino-1H-pyrazol-1-yl)tetrahydro-2H-pyran

1-(oxan-4-yl)pyrazol-4-amine

4-Amino-1-(4-tetrahydropyranyl)pyrazole

1-(oxan-4-yl)-1H-pyrazol-4-amine

1H-Pyrazol-4-amine, 1-(tetrahydro-2H-pyran-4-yl)-

1-(Tetrahydropyran-4-yl)pyrazol-4-amine

1190380-49-4

Amines

Pyrazoles & Triazoles