2-Fluoronicotinamide
- Product Name
- 2-Fluoronicotinamide
- CAS No.
- 364-22-7
- Chemical Name
- 2-Fluoronicotinamide
- Synonyms
- 2-Fluoronicotinamide;Pafolacianine Impurity 32;2-fluoro-nicotinic acid aMide;2-fluoro-3-Pyridinecarboxamide;2-fluoropyridine-3-carboxamide;3-Pyridinecarboxamide, 2-fluoro-
- CBNumber
- CB41873825
- Molecular Formula
- C6H5FN2O
- Formula Weight
- 140.12
- MOL File
- 364-22-7.mol
2-Fluoronicotinamide Property
- Melting point:
- 120.9-122 °C
- Boiling point:
- 287.9±25.0 °C(Predicted)
- Density
- 1.327±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.10±0.50(Predicted)
- form
- crystalline powder
- color
- White to off white
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- F593713
- Product name
- 2-Fluoronicotinamide
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 072674
- Product name
- 2-Fluoronicotinamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $825
- Updated
- 2021/12/16
- Product number
- HCH0143555
- Product name
- 2-FLUORONICOTINAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1235.85
- Updated
- 2021/12/16
- Product number
- HCH0143555
- Product name
- 2-FLUORONICOTINAMIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2517.9
- Updated
- 2021/12/16
- Product number
- 072674
- Product name
- 2-Fluoronicotinamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
2-Fluoronicotinamide Chemical Properties,Usage,Production
Synthesis
393-55-5
364-22-7
General procedure for the synthesis of 2-fluoronicotinamide from 2-fluoronicotinic acid: thionyl chloride (40 mL) was added to 2-fluoronicotinic acid (2.0 g, 14.3 mmol) and the reaction mixture was refluxed for 18 hours. Upon completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. Benzene (100 mL) was added to the residue, followed by passing ammonia into the suspension for 3 hours. The reaction flask was sealed and stirring was continued for 18 hours, after which it was concentrated under reduced pressure. Water was added to the residue and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 2-fluoronicotinamide (0.6 g, 30% yield). Mass spectrum (electrospray ionization, ES) showed m/z 141.1 ([M + H]+). 1H NMR (400 MHz, CDCl3) δ 8.32 (d, 1H, J = 4.5 Hz), 8.17 (m, 1H), 7.92 (br s, 1H), 7.79 (br s, 1H), 7.44 (m, 1H).
References
[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 61
[2] Journal of the Chemical Society, 1951, p. 3512
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 1125
2-Fluoronicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
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